TY - JOUR
T1 - Excitability Changes in Hippocampal Granule Cells of Senescent Rat
AU - Barnes, C. A.
AU - McNaughton, B. L.
N1 - Funding Information:
We would like to thank Prof. P. Andersen for the use of his laboratory facilities and Dr. H. Rigter and Organon International B. V., Oss, The Netherlands, for the gift of the animals. This work was supported by postdoctoral fellowships from the National Institute on Aging (U.S.A.) to C.A.B. and from the NSERC (Canada) to B.L.M.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Research on senescent nervous systems has tended to emphasize processes of deterioration, which may be among the most obvious and important kinds of alterations to occur over the lifespan. A number of recent findings, however, suggest that preservation of function, in spite of deteriorative change, occurs at many levels of the nervous system. One example of a seemingly compensatory change in senescent rat brain function is an increased electrical excitability of hippocampal granule cells in the face of a considerable reduction in the afferent fiber population. This chapter examines one possible mechanism of this change.
AB - Research on senescent nervous systems has tended to emphasize processes of deterioration, which may be among the most obvious and important kinds of alterations to occur over the lifespan. A number of recent findings, however, suggest that preservation of function, in spite of deteriorative change, occurs at many levels of the nervous system. One example of a seemingly compensatory change in senescent rat brain function is an increased electrical excitability of hippocampal granule cells in the face of a considerable reduction in the afferent fiber population. This chapter examines one possible mechanism of this change.
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U2 - 10.1016/S0079-6123(08)60047-3
DO - 10.1016/S0079-6123(08)60047-3
M3 - Article
C2 - 6635202
AN - SCOPUS:0020696862
VL - 58
SP - 445
EP - 451
JO - Progress in Brain Research
JF - Progress in Brain Research
SN - 0079-6123
IS - C
ER -