TY - JOUR
T1 - Excitability Changes in Hippocampal Granule Cells of Senescent Rat
AU - Barnes, C. A.
AU - McNaughton, B. L.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Research on senescent nervous systems has tended to emphasize processes of deterioration, which may be among the most obvious and important kinds of alterations to occur over the lifespan. A number of recent findings, however, suggest that preservation of function, in spite of deteriorative change, occurs at many levels of the nervous system. One example of a seemingly compensatory change in senescent rat brain function is an increased electrical excitability of hippocampal granule cells in the face of a considerable reduction in the afferent fiber population. This chapter examines one possible mechanism of this change.
AB - Research on senescent nervous systems has tended to emphasize processes of deterioration, which may be among the most obvious and important kinds of alterations to occur over the lifespan. A number of recent findings, however, suggest that preservation of function, in spite of deteriorative change, occurs at many levels of the nervous system. One example of a seemingly compensatory change in senescent rat brain function is an increased electrical excitability of hippocampal granule cells in the face of a considerable reduction in the afferent fiber population. This chapter examines one possible mechanism of this change.
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U2 - 10.1016/S0079-6123(08)60047-3
DO - 10.1016/S0079-6123(08)60047-3
M3 - Article
C2 - 6635202
AN - SCOPUS:0020696862
VL - 58
SP - 445
EP - 451
JO - Progress in Brain Research
JF - Progress in Brain Research
SN - 0079-6123
IS - C
ER -