Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats

Carol A Barnes, M. J. Forster, M. Fleshner, E. N. Ahanotu, M. L. Laudenslager, R. S. Mazzeo, S. F. Maier, H. Lal

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Old F-344 rats were given endurance training over a 10-week period on a motorized treadmill. This treatment resulted in substantial heart-to-body weight ratio increases, indicative of effective training. To determine whether endurance training might alter some of the known immune system and cognitive changes observed during aging, exercised old rats were compared to nonexercised old and young controls on three variables: in vivo antigen-specific immune activity, brain-reactive antibody formation, and spatial memory. The exercise training did not influence any of these measures in the old rats. Both groups of old rats showed poorer antibody response to a specific antigen, more brain-reactive antibody formation, and poorer spatial memory than the young controls. There was, however, a significant relationship between brain-reactive antibody formation and spatial memory performance, regardless of training condition.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalNeurobiology of Aging
Volume12
Issue number1
DOIs
StatePublished - 1991

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Autoimmunity
Antibody Formation
Brain
Antigens
Immune System
Body Weight
Exercise
Spatial Memory

Keywords

  • Autoimmunity
  • Brain-reactive antibodies
  • Exercise and aging
  • KLH serum antibodies
  • Spatial memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Barnes, C. A., Forster, M. J., Fleshner, M., Ahanotu, E. N., Laudenslager, M. L., Mazzeo, R. S., ... Lal, H. (1991). Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats. Neurobiology of Aging, 12(1), 47-53. https://doi.org/10.1016/0197-4580(91)90038-L

Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats. / Barnes, Carol A; Forster, M. J.; Fleshner, M.; Ahanotu, E. N.; Laudenslager, M. L.; Mazzeo, R. S.; Maier, S. F.; Lal, H.

In: Neurobiology of Aging, Vol. 12, No. 1, 1991, p. 47-53.

Research output: Contribution to journalArticle

Barnes, CA, Forster, MJ, Fleshner, M, Ahanotu, EN, Laudenslager, ML, Mazzeo, RS, Maier, SF & Lal, H 1991, 'Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats', Neurobiology of Aging, vol. 12, no. 1, pp. 47-53. https://doi.org/10.1016/0197-4580(91)90038-L
Barnes, Carol A ; Forster, M. J. ; Fleshner, M. ; Ahanotu, E. N. ; Laudenslager, M. L. ; Mazzeo, R. S. ; Maier, S. F. ; Lal, H. / Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats. In: Neurobiology of Aging. 1991 ; Vol. 12, No. 1. pp. 47-53.
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