Exercise-induced endocannabinoid signaling is modulated by intensity

David A. Raichlen, Adam D. Foster, Alexandre Seillier, Andrea Giuffrida, Gregory L. Gerdeman

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Endocannabinoids (eCB) are endogenous ligands for cannabinoid receptors that are densely expressed in brain networks responsible for reward. Recent work shows that exercise activates the eCB system in humans and other mammals, suggesting eCBs are partly responsible for the reported improvements in mood and affect following aerobic exercise in humans. However, exercise-induced psychological changes reported by runners are known to be dependent on exercise intensity, suggesting that any underlying molecular mechanism should also change with varying levels of exercise intensity. Here, we examine circulating levels of eCBs following aerobic exercise (treadmill running) in recreationally fit human runners at four different intensities. We show that eCB signaling is indeed intensity dependent, with significant changes in circulating eCBs observed following moderate intensities only (very high and very low intensity exercises do not significantly alter circulating eCB levels). Our results are consistent with intensity-dependent psychological state changes with exercise and therefore support the hypothesis that eCB activity is related to neurobiological effects of exercise. Thus, future studies examining the role of exercise-induced eCB signaling on neurobiology or physiology must take exercise intensity into account.

Original languageEnglish (US)
Pages (from-to)869-875
Number of pages7
JournalEuropean Journal of Applied Physiology
Volume113
Issue number4
DOIs
StatePublished - Apr 1 2013

Keywords

  • 2-AG
  • AEA
  • Analgesia
  • Endurance running
  • Neurogenesis
  • Positive affect

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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