Exercise training prevents development of cardiac contractile dysfunction in hypertensive TG(mREN2)27 rats

R. Tyler Morris, Deborah M. Fine, Simon J. Lees, Frank W. Booth, C. Daniel Link, Carlos M. Ferrario, Craig S Stump, James R. Sowers

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5 Scopus citations


Angiotensin II (Ang II) contributes to cardiac remodeling and left ventricular (LV) dysfunction. In contrast, exercise may have beneficial effects on LV structure and function. We investigated the effects of low-intensity exercise training (ET) on in-vivo cardiac function in hypertensive TG(mREN-2)27 rats (Ren2), which develop LV hypertrophy and dysfunction. Ren2 rats and Sprague-Dawley (SD) controls (4 to 5 weeks) began treadmill exercise every day for 5 to 6 weeks. Cardiac function was evaluated by echocardiography. Cardiac output and stroke volume were increased by ET in both the 8-week-old SD and Ren2. Slope of mitral deceleration time, a noninvasive measure of diastolic function, was lower in the Ren2 rats, but not changed by ET. LV collagen deposition, as assessed by hydroxyproline assay, was not affected by rat strain or ET at 10 to 11 weeks of age. LV B-type natriuretic peptide mRNA levels were higher in the Ren2 rats (100%), but not affected by ET. Both α (∼14.5-fold) and β (∼2.5-fold) myosin heavy chain mRNA were higher in the LV of Ren2 rats (P < .05), but were not changed by ET. Low-intensity exercise training in Ren2 rats, a model of Ang-II-mediated hypertension, maintains cardiac index and stroke volume in the presence of impaired diastolic function at 8 weeks of age.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalJournal of the American Society of Hypertension
Issue number6
Publication statusPublished - Nov 2007
Externally publishedYes



  • exercise
  • heart
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Morris, R. T., Fine, D. M., Lees, S. J., Booth, F. W., Link, C. D., Ferrario, C. M., ... Sowers, J. R. (2007). Exercise training prevents development of cardiac contractile dysfunction in hypertensive TG(mREN2)27 rats. Journal of the American Society of Hypertension, 1(6), 393-399. https://doi.org/10.1016/j.jash.2007.09.001