Exhaled ethane and antioxidant vitamin supplements in active smokers

Bao Khanh Q Do, Harinder S. Garewal, Neil C. Clements, Yei Mei Peng, Michael P Habib

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

To determine the effect of nutritional agents on lipid peroxidation, 10 smokers were given 6 mg betacarotene, 200 IU vitamin E, and 250 mg vitamin C 4 times daily for 3 weeks. Lipid peroxidation was assessed by measuring baseline and postsupplementation levels of exhaled ethane. There was a 29% decrease in mean (± SD) exhaled ethane (4.06 ± 1.49 vs 2.90 ± 1.29 pmol · kg-1 · min-1), with individual levels decreasing in 8 of the 10 smokers (p<0.05, Wilcoxon sign rank test). Three nonsmokers had very low baseline levels of ethane that did not change with supplementation. Ethane production correlated with active (packs per day) and lifelong (pack-years) tobacco consumption. Also, a strong correlation was found between the decline in ethane output after micronutrient supplementation and the presupplement FEV1. Therefore, antioxidant vitamin supplementation resulted in attenuation of smoking-related lipid peroxidation, and the decreases in ethane production appears to be associated with preserved lung function.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalChest
Volume110
Issue number1
StatePublished - 1996

Fingerprint

Ethane
Vitamins
Antioxidants
Lipid Peroxidation
Selegiline
Micronutrients
beta Carotene
Tobacco Use
Nonparametric Statistics
Vitamin E
Ascorbic Acid
Smoking
Lung

Keywords

  • ascorbic acid
  • carotene
  • ethane
  • lipid peroxidation
  • smoking
  • vitamin E

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Do, B. K. Q., Garewal, H. S., Clements, N. C., Peng, Y. M., & Habib, M. P. (1996). Exhaled ethane and antioxidant vitamin supplements in active smokers. Chest, 110(1), 159-164.

Exhaled ethane and antioxidant vitamin supplements in active smokers. / Do, Bao Khanh Q; Garewal, Harinder S.; Clements, Neil C.; Peng, Yei Mei; Habib, Michael P.

In: Chest, Vol. 110, No. 1, 1996, p. 159-164.

Research output: Contribution to journalArticle

Do, BKQ, Garewal, HS, Clements, NC, Peng, YM & Habib, MP 1996, 'Exhaled ethane and antioxidant vitamin supplements in active smokers', Chest, vol. 110, no. 1, pp. 159-164.
Do BKQ, Garewal HS, Clements NC, Peng YM, Habib MP. Exhaled ethane and antioxidant vitamin supplements in active smokers. Chest. 1996;110(1):159-164.
Do, Bao Khanh Q ; Garewal, Harinder S. ; Clements, Neil C. ; Peng, Yei Mei ; Habib, Michael P. / Exhaled ethane and antioxidant vitamin supplements in active smokers. In: Chest. 1996 ; Vol. 110, No. 1. pp. 159-164.
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