Exit from quiescence displays a memory of cell growth and division

Xia Wang, Kotaro Fujimaki, Geoffrey C. Mitchell, Jungeun Sarah Kwon, Kimiko Della Croce, Chris Langsdorf, Hao Helen Zhang, Guang Yao

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

Reactivating quiescent cells to proliferate is critical to tissue repair and homoeostasis. Quiescence exit is highly noisy even for genetically identical cells under the same environmental conditions. Deregulation of quiescence exit is associated with many diseases, but cellular mechanisms underlying the noisy process of exiting quiescence are poorly understood. Here we show that the heterogeneity of quiescence exit reflects a memory of preceding cell growth at quiescence induction and immediate division history before quiescence entry, and that such a memory is reflected in cell size at a coarse scale. The deterministic memory effects of preceding cell cycle, coupled with the stochastic dynamics of an Rb-E2F bistable switch, jointly and quantitatively explain quiescence-exit heterogeneity. As such, quiescence can be defined as a distinct state outside of the cell cycle while displaying a sequential cell order reflecting preceding cell growth and division variations.

LanguageEnglish (US)
Article number321
JournalNature Communications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

Cell growth
Data storage equipment
division
cells
Cell Division
Growth
Cells
cycles
Cell Cycle
Deregulation
Repair
History
Switches
Tissue
homeostasis
entry
induction
switches
histories
Cell Size

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Wang, X., Fujimaki, K., Mitchell, G. C., Kwon, J. S., Della Croce, K., Langsdorf, C., ... Yao, G. (2017). Exit from quiescence displays a memory of cell growth and division. Nature Communications, 8(1), [321]. DOI: 10.1038/s41467-017-00367-0

Exit from quiescence displays a memory of cell growth and division. / Wang, Xia; Fujimaki, Kotaro; Mitchell, Geoffrey C.; Kwon, Jungeun Sarah; Della Croce, Kimiko; Langsdorf, Chris; Zhang, Hao Helen; Yao, Guang.

In: Nature Communications, Vol. 8, No. 1, 321, 01.12.2017.

Research output: Research - peer-reviewArticle

Wang, X, Fujimaki, K, Mitchell, GC, Kwon, JS, Della Croce, K, Langsdorf, C, Zhang, HH & Yao, G 2017, 'Exit from quiescence displays a memory of cell growth and division' Nature Communications, vol 8, no. 1, 321. DOI: 10.1038/s41467-017-00367-0
Wang X, Fujimaki K, Mitchell GC, Kwon JS, Della Croce K, Langsdorf C et al. Exit from quiescence displays a memory of cell growth and division. Nature Communications. 2017 Dec 1;8(1). 321. Available from, DOI: 10.1038/s41467-017-00367-0
Wang, Xia ; Fujimaki, Kotaro ; Mitchell, Geoffrey C. ; Kwon, Jungeun Sarah ; Della Croce, Kimiko ; Langsdorf, Chris ; Zhang, Hao Helen ; Yao, Guang. / Exit from quiescence displays a memory of cell growth and division. In: Nature Communications. 2017 ; Vol. 8, No. 1.
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