Expanding functionality of commercial optical coherence tomography systems by integrating a custom endoscope

Weston A. Welge, Jennifer K Barton

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) is a useful imaging modality for detecting and monitoring diseases of the gastrointestinal tract and other tubular structures. The non-destructiveness of OCT enables time-serial studies in animal models. While turnkey commercial research OCT systems are plenty, researchers often require custom imaging probes. We describe the integration of a custom endoscope with a commercial swept-source OCT system and generalize this description to any imaging probe and OCT system. A numerical dispersion compensation method is also described. Example images demonstrate that OCT can visualize the mouse colon crypt structure and detect adenoma in vivo.

Original languageEnglish (US)
Article numbere0139396
JournalPLoS One
Volume10
Issue number9
DOIs
StatePublished - Sep 29 2015

Fingerprint

endoscopes
Endoscopy
Endoscopes
Optical tomography
tomography
Optical Coherence Tomography
image analysis
Imaging techniques
probes (equipment)
Dispersion compensation
Time and motion study
disease surveillance
adenoma
Adenoma
colon
gastrointestinal system
Gastrointestinal Tract
Colon
Animals
Animal Models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Expanding functionality of commercial optical coherence tomography systems by integrating a custom endoscope. / Welge, Weston A.; Barton, Jennifer K.

In: PLoS One, Vol. 10, No. 9, e0139396, 29.09.2015.

Research output: Contribution to journalArticle

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