Expanding functionality of commercial optical coherence tomography systems by integrating a custom endoscope

Weston A. Welge, Jennifer K. Barton

Research output: Contribution to journalArticle

6 Scopus citations


Optical coherence tomography (OCT) is a useful imaging modality for detecting and monitoring diseases of the gastrointestinal tract and other tubular structures. The non-destructiveness of OCT enables time-serial studies in animal models. While turnkey commercial research OCT systems are plenty, researchers often require custom imaging probes. We describe the integration of a custom endoscope with a commercial swept-source OCT system and generalize this description to any imaging probe and OCT system. A numerical dispersion compensation method is also described. Example images demonstrate that OCT can visualize the mouse colon crypt structure and detect adenoma in vivo.

Original languageEnglish (US)
Article numbere0139396
JournalPloS one
Issue number9
StatePublished - Sep 29 2015


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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