Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition

Michael Umkehrer, Günther Ross, Nadine Jäger, Christoph Burdack, Jürgen Kolb, Hong Hu, Maria Alvim-Gaston, Christopher Hulme

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.

Original languageEnglish (US)
Pages (from-to)2213-2216
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number12
DOIs
StatePublished - Mar 19 2007
Externally publishedYes

Fingerprint

Cycloaddition
Cycloaddition Reaction
Scaffolds
Libraries
imidazo(1,2-c)pyrimidine

Keywords

  • [4+1]-Cycloaddition
  • Combinatorial chemistry
  • Imidazo[1,2-c]pyrimidines
  • Three component condensation (3CC)

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition. / Umkehrer, Michael; Ross, Günther; Jäger, Nadine; Burdack, Christoph; Kolb, Jürgen; Hu, Hong; Alvim-Gaston, Maria; Hulme, Christopher.

In: Tetrahedron Letters, Vol. 48, No. 12, 19.03.2007, p. 2213-2216.

Research output: Contribution to journalArticle

Umkehrer, M, Ross, G, Jäger, N, Burdack, C, Kolb, J, Hu, H, Alvim-Gaston, M & Hulme, C 2007, 'Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition', Tetrahedron Letters, vol. 48, no. 12, pp. 2213-2216. https://doi.org/10.1016/j.tetlet.2007.01.061
Umkehrer M, Ross G, Jäger N, Burdack C, Kolb J, Hu H et al. Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition. Tetrahedron Letters. 2007 Mar 19;48(12):2213-2216. https://doi.org/10.1016/j.tetlet.2007.01.061
Umkehrer, Michael ; Ross, Günther ; Jäger, Nadine ; Burdack, Christoph ; Kolb, Jürgen ; Hu, Hong ; Alvim-Gaston, Maria ; Hulme, Christopher. / Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 12. pp. 2213-2216.
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