Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition

Michael Umkehrer, Günther Ross, Nadine Jäger, Christoph Burdack, Jürgen Kolb, Hong Hu, Maria Alvim-Gaston, Christopher Hulme

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.

Original languageEnglish (US)
Pages (from-to)2213-2216
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number12
DOIs
StatePublished - Mar 19 2007
Externally publishedYes

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Keywords

  • Combinatorial chemistry
  • Imidazo[1,2-c]pyrimidines
  • Three component condensation (3CC)
  • [4+1]-Cycloaddition

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Umkehrer, M., Ross, G., Jäger, N., Burdack, C., Kolb, J., Hu, H., Alvim-Gaston, M., & Hulme, C. (2007). Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition. Tetrahedron Letters, 48(12), 2213-2216. https://doi.org/10.1016/j.tetlet.2007.01.061