Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds

W. Banner, M. Koch, D. M. Capin, S. B. Hopf, S. Chang, T. G. Tong

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

The usefulness of N-acetylcysteine (NAC) as a chelating agent was studied for the toxin potassium dichromate, lead tetraacetate, and boric acid. Mature Sprague-Dawley rats were intoxicated with these substances and placed in metabolic cages. Urinary excretion rates of intoxicant and total urine volume were determined during treatment with N-acetylcysteine, calcium EDTA, and/or dimercaptosuccinic acid, N-acetylcysteine proved to be the most effective agent at increasing the excretion of chromium and boron and was also able to reverse the oliguria associated with these toxins. Dimercaptosuccinic acid was most effective at the chelation of lead. NAC did not increase the excretion of lead. We conclude that NAC may be useful in intoxications due to chromate and borate and is effective at reversing the oliguria associated with these intoxicants.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalToxicology and Applied Pharmacology
Volume83
Issue number1
DOIs
StatePublished - Mar 30 1986

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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