Experimental diabetes reduces circulating 1,25-dihydroxyvitamin D in the rat

Louis E. Schneider, Harold P. Schedl, Toni McCain, Mark R. Haussler

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Abstract

Duodenal calcium absorption and a vitamin D-dependent duodenal calcium- binding protein are depressed in rats with alloxan- or streptozotocin-induced diabetes. To test for possible abnormal vitamin D metabolism in diabetes we measured serum concentrations of25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in control, streptozotocin diabetic, and insulin-treated diabetic rats. The serum concentration of 1,25-dihydroxyvitamin D was depressed in untreated diabetic rats to one eighth of the level in controls and was restored to control levels by insulin treatment. The serum concentration of 25-hydroxyvitamin D was the same in all three groups. Hence, effects of diabetes on duodenal calcium transport can be explained by reduced concentrations of 1,25-dihydroxyvitamin D resulting eitherfrom failure of renal la-hydroxylation of 25-hydroxyvitamin D or increased catabolism of 1,25-dihydroxyvitamin D.

Original languageEnglish (US)
Pages (from-to)1452-1454
Number of pages3
JournalScience
Volume196
Issue number4297
DOIs
StatePublished - Jan 1 1977

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