Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system

Jacob Y. Hesterman, Matthew A Kupinski, Lars R Furenlid, Donald W. Wilson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

We have previously utilized lumpy object models and simulated imaging systems in conjunction with the ideal observer to compute figures of merit for hardware optimization. In this paper, we describe the development of methods and phantoms necessary to validate or experimentally carry out these optimizations. Our study was conducted on a four-camera small-animal SPECT system that employs interchangeable pinhole plates to operate under a variety of pinhole configurations and magnifications (representing optimizable system parameters). We developed a small-animal phantom capable of producing random backgrounds for each image sequence. The task chosen for the study was the detection of a 2mm diameter sphere within the phantom-generated random background. A total of 138 projection images were used, half of which included the signal. As our observer, we employed the channelized Hotelling observer (CHO) with Laguerre-Gauss channels. The signal-to-noise (SNR) of this observer was used to compare different system configurations. Results indicate agreement between experimental and simulated data with higher detectability rates found for multiple-camera, multiple-pinhole, and high-magnification systems, although it was found that mixtures of magnifications often outperform systems employing a single magnification. This work will serve as a basis for future studies pertaining to system hardware optimization.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsM.P. Eckstein, Y. Jiang
Pages300-309
Number of pages10
Volume5749
DOIs
StatePublished - 2005
EventMedical Imaging 2005 - Image Perception, Observer Performance, and Technology Assessment - San Diego, CA, United States
Duration: Feb 15 2005Feb 17 2005

Other

OtherMedical Imaging 2005 - Image Perception, Observer Performance, and Technology Assessment
CountryUnited States
CitySan Diego, CA
Period2/15/052/17/05

Fingerprint

SPECT
pinholes
magnification
animals
Animals
Camera
Cameras
cameras
optimization
Optimization
Observer
Phantom
Hardware
hardware
Imaging systems
configurations
figure of merit
Configuration
Detectability
projection

ASJC Scopus subject areas

  • Engineering(all)
  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Hesterman, J. Y., Kupinski, M. A., Furenlid, L. R., & Wilson, D. W. (2005). Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system. In M. P. Eckstein, & Y. Jiang (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5749, pp. 300-309). [34] https://doi.org/10.1117/12.594386

Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system. / Hesterman, Jacob Y.; Kupinski, Matthew A; Furenlid, Lars R; Wilson, Donald W.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / M.P. Eckstein; Y. Jiang. Vol. 5749 2005. p. 300-309 34.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hesterman, JY, Kupinski, MA, Furenlid, LR & Wilson, DW 2005, Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system. in MP Eckstein & Y Jiang (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5749, 34, pp. 300-309, Medical Imaging 2005 - Image Perception, Observer Performance, and Technology Assessment, San Diego, CA, United States, 2/15/05. https://doi.org/10.1117/12.594386
Hesterman JY, Kupinski MA, Furenlid LR, Wilson DW. Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system. In Eckstein MP, Jiang Y, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5749. 2005. p. 300-309. 34 https://doi.org/10.1117/12.594386
Hesterman, Jacob Y. ; Kupinski, Matthew A ; Furenlid, Lars R ; Wilson, Donald W. / Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / M.P. Eckstein ; Y. Jiang. Vol. 5749 2005. pp. 300-309
@inproceedings{7966f9fac4ce4c5a9492b2c99cb3bf33,
title = "Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system",
abstract = "We have previously utilized lumpy object models and simulated imaging systems in conjunction with the ideal observer to compute figures of merit for hardware optimization. In this paper, we describe the development of methods and phantoms necessary to validate or experimentally carry out these optimizations. Our study was conducted on a four-camera small-animal SPECT system that employs interchangeable pinhole plates to operate under a variety of pinhole configurations and magnifications (representing optimizable system parameters). We developed a small-animal phantom capable of producing random backgrounds for each image sequence. The task chosen for the study was the detection of a 2mm diameter sphere within the phantom-generated random background. A total of 138 projection images were used, half of which included the signal. As our observer, we employed the channelized Hotelling observer (CHO) with Laguerre-Gauss channels. The signal-to-noise (SNR) of this observer was used to compare different system configurations. Results indicate agreement between experimental and simulated data with higher detectability rates found for multiple-camera, multiple-pinhole, and high-magnification systems, although it was found that mixtures of magnifications often outperform systems employing a single magnification. This work will serve as a basis for future studies pertaining to system hardware optimization.",
author = "Hesterman, {Jacob Y.} and Kupinski, {Matthew A} and Furenlid, {Lars R} and Wilson, {Donald W.}",
year = "2005",
doi = "10.1117/12.594386",
language = "English (US)",
volume = "5749",
pages = "300--309",
editor = "M.P. Eckstein and Y. Jiang",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system

AU - Hesterman, Jacob Y.

AU - Kupinski, Matthew A

AU - Furenlid, Lars R

AU - Wilson, Donald W.

PY - 2005

Y1 - 2005

N2 - We have previously utilized lumpy object models and simulated imaging systems in conjunction with the ideal observer to compute figures of merit for hardware optimization. In this paper, we describe the development of methods and phantoms necessary to validate or experimentally carry out these optimizations. Our study was conducted on a four-camera small-animal SPECT system that employs interchangeable pinhole plates to operate under a variety of pinhole configurations and magnifications (representing optimizable system parameters). We developed a small-animal phantom capable of producing random backgrounds for each image sequence. The task chosen for the study was the detection of a 2mm diameter sphere within the phantom-generated random background. A total of 138 projection images were used, half of which included the signal. As our observer, we employed the channelized Hotelling observer (CHO) with Laguerre-Gauss channels. The signal-to-noise (SNR) of this observer was used to compare different system configurations. Results indicate agreement between experimental and simulated data with higher detectability rates found for multiple-camera, multiple-pinhole, and high-magnification systems, although it was found that mixtures of magnifications often outperform systems employing a single magnification. This work will serve as a basis for future studies pertaining to system hardware optimization.

AB - We have previously utilized lumpy object models and simulated imaging systems in conjunction with the ideal observer to compute figures of merit for hardware optimization. In this paper, we describe the development of methods and phantoms necessary to validate or experimentally carry out these optimizations. Our study was conducted on a four-camera small-animal SPECT system that employs interchangeable pinhole plates to operate under a variety of pinhole configurations and magnifications (representing optimizable system parameters). We developed a small-animal phantom capable of producing random backgrounds for each image sequence. The task chosen for the study was the detection of a 2mm diameter sphere within the phantom-generated random background. A total of 138 projection images were used, half of which included the signal. As our observer, we employed the channelized Hotelling observer (CHO) with Laguerre-Gauss channels. The signal-to-noise (SNR) of this observer was used to compare different system configurations. Results indicate agreement between experimental and simulated data with higher detectability rates found for multiple-camera, multiple-pinhole, and high-magnification systems, although it was found that mixtures of magnifications often outperform systems employing a single magnification. This work will serve as a basis for future studies pertaining to system hardware optimization.

UR - http://www.scopus.com/inward/record.url?scp=24644474749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644474749&partnerID=8YFLogxK

U2 - 10.1117/12.594386

DO - 10.1117/12.594386

M3 - Conference contribution

AN - SCOPUS:24644474749

VL - 5749

SP - 300

EP - 309

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

A2 - Eckstein, M.P.

A2 - Jiang, Y.

ER -