Expiratory neural activities in gasping

W. M. St. John, D. Zhou, Ralph F Fregosi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The purpose was to characterize expiratory-related neural activities in eupnea and gasping. In decerebrate and vagotomized cats, activities were recorded from the phrenic nerve, spinal intercostal and abdominal nerves, and recurrent laryngeal nerve and its branches. Neural inspiration was defined by phrenic discharge. The spinal and laryngeal nerves discharged in inspiration, expiration, or during both phases. Gasping was induced by freezing the brain stem at the ponto-medullary junction, exposure to asphyxia or anoxia, or ligation of the basilar artery and its branches. In gasping, peak phrenic activity typically increased as did inspiratory-related activities of laryngeal and spinal nerves. Expiratory activities were greatly reduced in gasping, with some activities being completely eliminated. Reductions of expiratory activity were more prominent for spinal than laryngeal nerves. Similar results were obtained in cats having intact vagi that were ventilated with a servo-respirator so that lung inflation paralleled phrenic activity. The concept that gasping differs fundamentally from other ventilatory patterns is discussed.

Original languageEnglish (US)
Pages (from-to)223-231
Number of pages9
JournalJournal of Applied Physiology
Volume66
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

Laryngeal Nerves
Spinal Nerves
Diaphragm
Cats
Intercostal Nerves
Recurrent Laryngeal Nerve
Phrenic Nerve
Basilar Artery
Asphyxia
Economic Inflation
Mechanical Ventilators
Freezing
Brain Stem
Ligation
Lung

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Expiratory neural activities in gasping. / St. John, W. M.; Zhou, D.; Fregosi, Ralph F.

In: Journal of Applied Physiology, Vol. 66, No. 1, 1989, p. 223-231.

Research output: Contribution to journalArticle

St. John, WM, Zhou, D & Fregosi, RF 1989, 'Expiratory neural activities in gasping', Journal of Applied Physiology, vol. 66, no. 1, pp. 223-231.
St. John, W. M. ; Zhou, D. ; Fregosi, Ralph F. / Expiratory neural activities in gasping. In: Journal of Applied Physiology. 1989 ; Vol. 66, No. 1. pp. 223-231.
@article{15733138d8de463eaba159ca35ce7ac6,
title = "Expiratory neural activities in gasping",
abstract = "The purpose was to characterize expiratory-related neural activities in eupnea and gasping. In decerebrate and vagotomized cats, activities were recorded from the phrenic nerve, spinal intercostal and abdominal nerves, and recurrent laryngeal nerve and its branches. Neural inspiration was defined by phrenic discharge. The spinal and laryngeal nerves discharged in inspiration, expiration, or during both phases. Gasping was induced by freezing the brain stem at the ponto-medullary junction, exposure to asphyxia or anoxia, or ligation of the basilar artery and its branches. In gasping, peak phrenic activity typically increased as did inspiratory-related activities of laryngeal and spinal nerves. Expiratory activities were greatly reduced in gasping, with some activities being completely eliminated. Reductions of expiratory activity were more prominent for spinal than laryngeal nerves. Similar results were obtained in cats having intact vagi that were ventilated with a servo-respirator so that lung inflation paralleled phrenic activity. The concept that gasping differs fundamentally from other ventilatory patterns is discussed.",
author = "{St. John}, {W. M.} and D. Zhou and Fregosi, {Ralph F}",
year = "1989",
language = "English (US)",
volume = "66",
pages = "223--231",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Expiratory neural activities in gasping

AU - St. John, W. M.

AU - Zhou, D.

AU - Fregosi, Ralph F

PY - 1989

Y1 - 1989

N2 - The purpose was to characterize expiratory-related neural activities in eupnea and gasping. In decerebrate and vagotomized cats, activities were recorded from the phrenic nerve, spinal intercostal and abdominal nerves, and recurrent laryngeal nerve and its branches. Neural inspiration was defined by phrenic discharge. The spinal and laryngeal nerves discharged in inspiration, expiration, or during both phases. Gasping was induced by freezing the brain stem at the ponto-medullary junction, exposure to asphyxia or anoxia, or ligation of the basilar artery and its branches. In gasping, peak phrenic activity typically increased as did inspiratory-related activities of laryngeal and spinal nerves. Expiratory activities were greatly reduced in gasping, with some activities being completely eliminated. Reductions of expiratory activity were more prominent for spinal than laryngeal nerves. Similar results were obtained in cats having intact vagi that were ventilated with a servo-respirator so that lung inflation paralleled phrenic activity. The concept that gasping differs fundamentally from other ventilatory patterns is discussed.

AB - The purpose was to characterize expiratory-related neural activities in eupnea and gasping. In decerebrate and vagotomized cats, activities were recorded from the phrenic nerve, spinal intercostal and abdominal nerves, and recurrent laryngeal nerve and its branches. Neural inspiration was defined by phrenic discharge. The spinal and laryngeal nerves discharged in inspiration, expiration, or during both phases. Gasping was induced by freezing the brain stem at the ponto-medullary junction, exposure to asphyxia or anoxia, or ligation of the basilar artery and its branches. In gasping, peak phrenic activity typically increased as did inspiratory-related activities of laryngeal and spinal nerves. Expiratory activities were greatly reduced in gasping, with some activities being completely eliminated. Reductions of expiratory activity were more prominent for spinal than laryngeal nerves. Similar results were obtained in cats having intact vagi that were ventilated with a servo-respirator so that lung inflation paralleled phrenic activity. The concept that gasping differs fundamentally from other ventilatory patterns is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0024581711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024581711&partnerID=8YFLogxK

M3 - Article

C2 - 2917925

AN - SCOPUS:0024581711

VL - 66

SP - 223

EP - 231

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -