Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel

Jun Wang, Chunlong Ma, Yibing Wu, Robert A. Lamb, Lawrence H. Pinto, William F. Degrado

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

We describe the use of organosilanes as inhibitors and structural probes of a membrane protein, the M2 proton channel from influenza A virus. Organosilane amine inhibitors were found to be generally as potent as their carbon analogues in targeting WT A/M2 and more potent against the drug-resistant A/M2-V27A mutant. In addition, intermolecular NOESY spectra with dimethyl-substituted organosilane amine inhibitors clearly located the drug binding site at the N-terminal lumen of the A/M2 channel close to V27.

Original languageEnglish (US)
Pages (from-to)13844-13847
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number35
DOIs
StatePublished - Sep 7 2011
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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