Exploring the costs of horizontal gene transfer

Research output: Contribution to journalReview articlepeer-review

158 Scopus citations

Abstract

Horizontal gene transfer (HGT) is one of the most important evolutionary forces within microbial populations. Although evidence for beneficial fitness effects of HGT is overwhelming, recently acquired regions often function inefficiently within new genomic backgrounds so that each transfer event has the potential to disrupt existing regulatory and physiological networks. Identifying and exploring costs is essential for guiding general discussions about the interplay between selection and HGT, as well as generating hypotheses to explain how HGT affects evolutionary potential through, for example, changing adaptive trajectories. Focusing on costs of HGT as foundations for future studies will enhance exploration at the interface between acquired regions and recipient genomes, including the process of amelioration, and enable experimental evaluation of the role of HGT in structuring genetic diversity across populations.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalTrends in Ecology and Evolution
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2013

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

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