Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Victor J. Hruby, Minying Cai, Paolo Grieco, Guoxia Han, Malcolm Kavarana, Dev Trivedi

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The melanotropin peptides α-MSHH, γ-MSH, and β-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume994
DOIs
StatePublished - Jan 1 2003

Keywords

  • Agonists
  • Antagonists
  • Conformational constraint
  • Melanocortin receptors
  • Melanotropin peptides
  • Receptor selective melanotropins
  • α-melanocyte stimulating hormone (α-MSH)
  • γ-melanocyte-stimulating hormone (γ-MSH)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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