Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Victor J Hruby, Minying Cai, Paolo Grieco, Guoxia Han, Malcolm Kavarana, Dev Trivedi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The melanotropin peptides α-MSHH, γ-MSH, and β-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume994
StatePublished - 2003

Fingerprint

Melanocortin Receptors
Melanocyte-Stimulating Hormones
Ligands
Peptides
Peptide Receptors
Antagonist

Keywords

  • α-melanocyte stimulating hormone (α-MSH)
  • γ-melanocyte-stimulating hormone (γ-MSH)
  • Agonists
  • Antagonists
  • Conformational constraint
  • Melanocortin receptors
  • Melanotropin peptides
  • Receptor selective melanotropins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors. / Hruby, Victor J; Cai, Minying; Grieco, Paolo; Han, Guoxia; Kavarana, Malcolm; Trivedi, Dev.

In: Annals of the New York Academy of Sciences, Vol. 994, 2003, p. 12-20.

Research output: Contribution to journalArticle

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AU - Trivedi, Dev

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