Epidemiological evidence indicates that neonatal exposure to environmental tobacco smoke (ETS) can lead to alterations in lung growth and development in young infants and children. Because postnatal lung growth is potentially under the control of growth factors, experiments were performed to determine the effect of ETS exposure on growth factor expression in the neonatal lung. Pregnant Sprague Dawley females were exposed to either air or ETS (1 hour/day, 5 days/week) until birth of the pups. After birth, the pups were exposed to either air or ETS until they were sacrificed. Morphometric data indicated that ETS exposure resulted in larger and fewer alveoli than in the controls with concomitant decreases in lung surface area. Levels of mRNA for transforming growth factor-betal (TGFβ1) and hepatocyte growth factor (HGF) were determined at 7 and 14 days after birth. Data indicate that TGFβ1 expression is high on day 7, declining on day 14. Exposure to ETS did not alter TGFβ1 expression. Conversely, expression of HGF was not different on days 7 and 14. However, ETS exposure decreased HGF expression on both days. ETS-induced decreased growth factor expression may lead to morphological alterations in the neonatal lung.
|Original language||English (US)|
|State||Published - Mar 20 1998|
ASJC Scopus subject areas
- Molecular Biology