Exposure to sidestream cigarette smoke alters growth factor expression in neonatal lung

Robert Clark Lantz, M. L. Witten, P. Sundareshan, C. Song, E. Rider, B. Leung, M. Balagtas, N. Lawrence

Research output: Contribution to journalArticle

Abstract

Epidemiological evidence indicates that neonatal exposure to environmental tobacco smoke (ETS) can lead to alterations in lung growth and development in young infants and children. Because postnatal lung growth is potentially under the control of growth factors, experiments were performed to determine the effect of ETS exposure on growth factor expression in the neonatal lung. Pregnant Sprague Dawley females were exposed to either air or ETS (1 hour/day, 5 days/week) until birth of the pups. After birth, the pups were exposed to either air or ETS until they were sacrificed. Morphometric data indicated that ETS exposure resulted in larger and fewer alveoli than in the controls with concomitant decreases in lung surface area. Levels of mRNA for transforming growth factor-betal (TGFβ1) and hepatocyte growth factor (HGF) were determined at 7 and 14 days after birth. Data indicate that TGFβ1 expression is high on day 7, declining on day 14. Exposure to ETS did not alter TGFβ1 expression. Conversely, expression of HGF was not different on days 7 and 14. However, ETS exposure decreased HGF expression on both days. ETS-induced decreased growth factor expression may lead to morphological alterations in the neonatal lung.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

Fingerprint

Tobacco
cigarettes
smoke
Smoke
Tobacco Products
growth factors
Intercellular Signaling Peptides and Proteins
tobacco
lungs
Lung
hepatocyte growth factor
Hepatocyte Growth Factor
Environmental Exposure
Parturition
pups
Air
air
transforming growth factors
Transforming Growth Factors
Growth and Development

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Lantz, R. C., Witten, M. L., Sundareshan, P., Song, C., Rider, E., Leung, B., ... Lawrence, N. (1998). Exposure to sidestream cigarette smoke alters growth factor expression in neonatal lung. FASEB Journal, 12(5).

Exposure to sidestream cigarette smoke alters growth factor expression in neonatal lung. / Lantz, Robert Clark; Witten, M. L.; Sundareshan, P.; Song, C.; Rider, E.; Leung, B.; Balagtas, M.; Lawrence, N.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

Lantz, RC, Witten, ML, Sundareshan, P, Song, C, Rider, E, Leung, B, Balagtas, M & Lawrence, N 1998, 'Exposure to sidestream cigarette smoke alters growth factor expression in neonatal lung', FASEB Journal, vol. 12, no. 5.
Lantz RC, Witten ML, Sundareshan P, Song C, Rider E, Leung B et al. Exposure to sidestream cigarette smoke alters growth factor expression in neonatal lung. FASEB Journal. 1998 Mar 20;12(5).
Lantz, Robert Clark ; Witten, M. L. ; Sundareshan, P. ; Song, C. ; Rider, E. ; Leung, B. ; Balagtas, M. ; Lawrence, N. / Exposure to sidestream cigarette smoke alters growth factor expression in neonatal lung. In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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