Expression of a MHC non-classical, class I gene, Q4, is similar to a classical class I gene, D(P)

J. E. Badley, Jeffrey A Frelinger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have investigated the effects of the cell cycle on expression of Q4 mRNA. Q4, the gene encoding the Qb-1 antigen, is transcribed in a wide variety of tissues, unlike many other non-classical class I genes. We have compared the pattern of Q4 transcription in the cell cycle to classical class I, β-2-microglobulin and actin. We found that the pattern of Q4 RNA levels resembles that of the classical class I genes, consistent with the similarity of the 5' sequences of Q4 and K/D. Thus, Q4 mRNA accumulates during the cell cycle along with the total RNA, but does not show specific transcriptional enhancement. This is consistent with a function for Q4 similar to the classical K/D gene products.

Original languageEnglish (US)
Pages (from-to)315-321
Number of pages7
JournalEuropean Journal of Immunogenetics
Volume18
Issue number5-6
StatePublished - 1991
Externally publishedYes

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MHC Class I Genes
Cell Cycle
RNA
Messenger RNA
Genes
Actins
Antigens

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Expression of a MHC non-classical, class I gene, Q4, is similar to a classical class I gene, D(P). / Badley, J. E.; Frelinger, Jeffrey A.

In: European Journal of Immunogenetics, Vol. 18, No. 5-6, 1991, p. 315-321.

Research output: Contribution to journalArticle

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