TY - JOUR
T1 - EXPRESSION OF A MHC NON‐CLASSICAL CLASS I GENE, 04, IS SIMILAR TO A CLASSICAL CLASS I GENE, Dp
AU - Badley, J. E.
AU - Frelinger, J. A.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/10
Y1 - 1991/10
N2 - We have investigated the effects of the cell cycle on expression of Q4 mRNA. Q4, the gene encoding the Qb‐1 antigen, is transcribed in a wide variety of tissues, unlike many other non‐classical class I genes. We have compared the pattern of Q4 transcription in the cell cycle to classical class I, β‐2‐microglobulin and actin. We found that the pattern of Q4 RNA levels resembles that of the classical class I genes, consistent with the similarity of the 5′sequences of Q4 and K/D. Thus, Q4 mRNA accumulates during the cell cycle along with the total RNA, but does not show specific transcriptional enhancement. This is consistent with a function for Q4 similar to the classical K/D gene products.
AB - We have investigated the effects of the cell cycle on expression of Q4 mRNA. Q4, the gene encoding the Qb‐1 antigen, is transcribed in a wide variety of tissues, unlike many other non‐classical class I genes. We have compared the pattern of Q4 transcription in the cell cycle to classical class I, β‐2‐microglobulin and actin. We found that the pattern of Q4 RNA levels resembles that of the classical class I genes, consistent with the similarity of the 5′sequences of Q4 and K/D. Thus, Q4 mRNA accumulates during the cell cycle along with the total RNA, but does not show specific transcriptional enhancement. This is consistent with a function for Q4 similar to the classical K/D gene products.
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U2 - 10.1111/j.1744-313X.1991.tb00031.x
DO - 10.1111/j.1744-313X.1991.tb00031.x
M3 - Article
C2 - 1772876
AN - SCOPUS:0025949312
VL - 18
SP - 315
EP - 321
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
SN - 1744-3121
IS - 5-6
ER -