EXPRESSION OF A MHC NON‐CLASSICAL CLASS I GENE, 04, IS SIMILAR TO A CLASSICAL CLASS I GENE, Dp

J. E. Badley, J. A. Frelinger

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We have investigated the effects of the cell cycle on expression of Q4 mRNA. Q4, the gene encoding the Qb‐1 antigen, is transcribed in a wide variety of tissues, unlike many other non‐classical class I genes. We have compared the pattern of Q4 transcription in the cell cycle to classical class I, β‐2‐microglobulin and actin. We found that the pattern of Q4 RNA levels resembles that of the classical class I genes, consistent with the similarity of the 5′sequences of Q4 and K/D. Thus, Q4 mRNA accumulates during the cell cycle along with the total RNA, but does not show specific transcriptional enhancement. This is consistent with a function for Q4 similar to the classical K/D gene products.

Original languageEnglish (US)
Pages (from-to)315-321
Number of pages7
JournalInternational Journal of Immunogenetics
Volume18
Issue number5-6
DOIs
StatePublished - Oct 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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