Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine

Todd D. Camenisch, Liliana Jaso-Friedmann, Donald L. Evans, David T. Harris

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In the present study, we have analyzed the effects of the anti-FAM mAb 5C6, on endogenous NK cell and lymphokineactivated killer (LAK) cell activity of swine. We report that the anti-FAM mAb 5C6 binds to fresh and cultured lymphocytes with spontaneous cytotoxic activity from swine peripheral blood. In conjunction, the anti-FAM mAb 5C6 inhibits swine cytolysis against K562 target cells. Inhibition was found to be mediated by blocking of conjugate formation. The level of spontaneous killing and mAb inhibition was correlated with the number of swine cells staining positive with the mAb 5C6 as assessed by flow cytometry.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalDevelopmental and Comparative Immunology
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1993

Keywords

  • Function-associated molecule
  • Natural killer
  • Nonspecific immunity
  • Spontaneous cytotoxicity
  • Swine lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine'. Together they form a unique fingerprint.

  • Cite this