Expression of I-A and I-E,C region-coded Ia antigens on functional B cell subpopulations

J. A. Frelinger, F. J. Hibbler, S. W. Hill

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Ia antigens from specific subregions have been examined on functional B cell populations. Expression of both I-A and I-E,C region antigens was demonstrated on cells required for both lipopolysaccharide mitogenesis and polyclonal activation. Similar I-A and I-E,C subregion expression was found on cells required for response to the T-independent antigen, polyvinylpyrrolidone. TNP-specific IgM and hen egg lysozyme-specific IgG plaque-forming cells also express I-A and I-E,C region antigens. No evidence was found for an Ia- population responsive in the system tested. Further, no evidence of preferential expression of I-A or I-E,C region antigens was observed in any system examined. Therefore, it appears that B cells express both I-A and I-E,C region-coded Ia antigens.

Original languageEnglish (US)
Pages (from-to)2376-2380
Number of pages5
JournalJournal of Immunology
Volume121
Issue number6
StatePublished - Dec 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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