Expression of insulin pathway genes during the period of caste determination in the honey bee, Apis mellifera

Diana E Wheeler, N. Buck, J. D. Evans

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Female honeybees have two castes, queens and workers. Developmental fate is determined by larval diet. Coding sequences made available through the Honey Bee Genome Sequencing Consortium allow for a pathway-based approach to understanding caste determination. We examined the expression of several genes of the insulin signalling pathway, which is central to regulation of growth based on nutrition. We found one insulin-like peptide expressed at very high levels in queen but not worker larvae. Also, the gene for an insulin receptor was expressed at higher levels in queen larvae during the 2nd larval instar. These results demonstrate that the insulin pathway is a compelling candidate for pursing the relationship between diet and downstream signals involved in caste determination and differentiation.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalInsect Molecular Biology
Volume15
Issue number5
DOIs
StatePublished - Oct 2006

Fingerprint

caste determination
Honey
Bees
Nutrition
queen insects
Apis mellifera
Social Class
honey bees
insulin
Genes
Insulin
Larva
Diet
genes
larvae
Insulin Receptor
diet
instars
Genome
peptides

Keywords

  • Caste determination
  • Chico
  • Insulin receptor
  • Insulin-like peptide
  • PTEN

ASJC Scopus subject areas

  • Insect Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Expression of insulin pathway genes during the period of caste determination in the honey bee, Apis mellifera. / Wheeler, Diana E; Buck, N.; Evans, J. D.

In: Insect Molecular Biology, Vol. 15, No. 5, 10.2006, p. 597-602.

Research output: Contribution to journalArticle

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