Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus

Karen E. Pilcher, Paul A Krieg

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Signaling by the Wnt family of secreted growth factors is involved in numerous different aspects of embryonic development and also for maintenance of cellular function in adult tissues. In addition to regulation at the transcriptional level, Wnt activity is modulated by a number of different Wnt-binding proteins. Here we report the cloning and developmental expression pattern of the Xenopus orthologue of secreted Frizzled-related protein 5 (sFRP5), an endogenous inhibitor of Wnt signaling. At early stages of endodermal differentiation, sFRP5 is expressed in the developing liver. At later stages however, sFRP5 expression is down-regulated in the liver and becomes strongly expressed in the region corresponding to the junction between the posterior portion of the stomach and the anterior intestines.

Original languageEnglish (US)
Pages (from-to)369-372
Number of pages4
JournalGene Expression Patterns
Volume2
Issue number3-4
DOIs
StatePublished - Dec 2002

Fingerprint

Endoderm
Xenopus
Wnt Proteins
Liver
Intestines
Embryonic Development
Organism Cloning
Intercellular Signaling Peptides and Proteins
Stomach
Carrier Proteins
Maintenance
FRZB protein
Xenopus Sfrp5 protein

Keywords

  • Endoderm
  • Frizzled-related protein
  • Intestines
  • Liver
  • sFRP5
  • Stomach
  • Xenopus

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus. / Pilcher, Karen E.; Krieg, Paul A.

In: Gene Expression Patterns, Vol. 2, No. 3-4, 12.2002, p. 369-372.

Research output: Contribution to journalArticle

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