Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression

Janine G Einspahr, Tracy L. Thomas, Kathylynn Saboda, Brian J. Nickolof, James A Warneke, Clara N Curiel, James Ranger-Moore, Laura Duckett, Jerry Bangert, John P. Fruehauf, David S Alberts

Research output: Contribution to journalArticle

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Abstract

BACKGROUND. A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN). Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesis could be useful as chemoprevention and prognostic markers. METHODS. Markers of angiogenesis that included expression of the vascular endothelial growth factor A (VEGF-A) and microvessel density counts (MVD) were evaluated in 13 prospectively collected benign nevi (BN) and 19 DN from 16 individuals and in a comparison group of 17 primary melanomas (16 archival samples and 1 prospective melanoma). RESULTS. VEGF expression in melanocytic cells (mean ± standard error [SE]) was low or absent in BN (3.4 ± 1.4), increased significantly in DN (41.0 ± 10.1; P = .0003 for BN vs DN), and increased further in primary melanoma (119.9 ± 28.3; P = .06 for DN vs melanoma). MVD using CD31 (mean ± SE [percentage x intensity]) followed a similar pattern with similarity between BN (2.6 ± 0.7; N = 13) and DN (2.2 ± 0.8; N = 19; P = .4 for BN vs DN), whereas primary melanomas were significantly higher (39.4 ± 6.4; N = 17; P = .0001 for BN or DN vs melanoma). CONCLUSIONS. In a prospective setting, the current data suggested that increased VEGF-A expression in DN may be a good indicator of preneoplastic change in melanocytic lesions with the potential for improving the understanding and prevention of the transformation of DN to melanoma.

Original languageEnglish (US)
Pages (from-to)2519-2527
Number of pages9
JournalCancer
Volume110
Issue number11
DOIs
StatePublished - Dec 1 2007

Fingerprint

Dysplastic Nevus Syndrome
Pigmented Nevus
Vascular Endothelial Growth Factor A
Nevus
Skin
Melanoma
Nevi and Melanomas
Microvessels
Chemoprevention
Biomarkers

Keywords

  • Angiogenesis
  • Dysplastic nevi
  • Melanoma
  • Microvessel density counts
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression. / Einspahr, Janine G; Thomas, Tracy L.; Saboda, Kathylynn; Nickolof, Brian J.; Warneke, James A; Curiel, Clara N; Ranger-Moore, James; Duckett, Laura; Bangert, Jerry; Fruehauf, John P.; Alberts, David S.

In: Cancer, Vol. 110, No. 11, 01.12.2007, p. 2519-2527.

Research output: Contribution to journalArticle

Einspahr, JG, Thomas, TL, Saboda, K, Nickolof, BJ, Warneke, JA, Curiel, CN, Ranger-Moore, J, Duckett, L, Bangert, J, Fruehauf, JP & Alberts, DS 2007, 'Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression', Cancer, vol. 110, no. 11, pp. 2519-2527. https://doi.org/10.1002/cncr.23076
Einspahr, Janine G ; Thomas, Tracy L. ; Saboda, Kathylynn ; Nickolof, Brian J. ; Warneke, James A ; Curiel, Clara N ; Ranger-Moore, James ; Duckett, Laura ; Bangert, Jerry ; Fruehauf, John P. ; Alberts, David S. / Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression. In: Cancer. 2007 ; Vol. 110, No. 11. pp. 2519-2527.
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abstract = "BACKGROUND. A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN). Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesis could be useful as chemoprevention and prognostic markers. METHODS. Markers of angiogenesis that included expression of the vascular endothelial growth factor A (VEGF-A) and microvessel density counts (MVD) were evaluated in 13 prospectively collected benign nevi (BN) and 19 DN from 16 individuals and in a comparison group of 17 primary melanomas (16 archival samples and 1 prospective melanoma). RESULTS. VEGF expression in melanocytic cells (mean ± standard error [SE]) was low or absent in BN (3.4 ± 1.4), increased significantly in DN (41.0 ± 10.1; P = .0003 for BN vs DN), and increased further in primary melanoma (119.9 ± 28.3; P = .06 for DN vs melanoma). MVD using CD31 (mean ± SE [percentage x intensity]) followed a similar pattern with similarity between BN (2.6 ± 0.7; N = 13) and DN (2.2 ± 0.8; N = 19; P = .4 for BN vs DN), whereas primary melanomas were significantly higher (39.4 ± 6.4; N = 17; P = .0001 for BN or DN vs melanoma). CONCLUSIONS. In a prospective setting, the current data suggested that increased VEGF-A expression in DN may be a good indicator of preneoplastic change in melanocytic lesions with the potential for improving the understanding and prevention of the transformation of DN to melanoma.",
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T1 - Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression

AU - Einspahr, Janine G

AU - Thomas, Tracy L.

AU - Saboda, Kathylynn

AU - Nickolof, Brian J.

AU - Warneke, James A

AU - Curiel, Clara N

AU - Ranger-Moore, James

AU - Duckett, Laura

AU - Bangert, Jerry

AU - Fruehauf, John P.

AU - Alberts, David S

PY - 2007/12/1

Y1 - 2007/12/1

N2 - BACKGROUND. A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN). Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesis could be useful as chemoprevention and prognostic markers. METHODS. Markers of angiogenesis that included expression of the vascular endothelial growth factor A (VEGF-A) and microvessel density counts (MVD) were evaluated in 13 prospectively collected benign nevi (BN) and 19 DN from 16 individuals and in a comparison group of 17 primary melanomas (16 archival samples and 1 prospective melanoma). RESULTS. VEGF expression in melanocytic cells (mean ± standard error [SE]) was low or absent in BN (3.4 ± 1.4), increased significantly in DN (41.0 ± 10.1; P = .0003 for BN vs DN), and increased further in primary melanoma (119.9 ± 28.3; P = .06 for DN vs melanoma). MVD using CD31 (mean ± SE [percentage x intensity]) followed a similar pattern with similarity between BN (2.6 ± 0.7; N = 13) and DN (2.2 ± 0.8; N = 19; P = .4 for BN vs DN), whereas primary melanomas were significantly higher (39.4 ± 6.4; N = 17; P = .0001 for BN or DN vs melanoma). CONCLUSIONS. In a prospective setting, the current data suggested that increased VEGF-A expression in DN may be a good indicator of preneoplastic change in melanocytic lesions with the potential for improving the understanding and prevention of the transformation of DN to melanoma.

AB - BACKGROUND. A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN). Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesis could be useful as chemoprevention and prognostic markers. METHODS. Markers of angiogenesis that included expression of the vascular endothelial growth factor A (VEGF-A) and microvessel density counts (MVD) were evaluated in 13 prospectively collected benign nevi (BN) and 19 DN from 16 individuals and in a comparison group of 17 primary melanomas (16 archival samples and 1 prospective melanoma). RESULTS. VEGF expression in melanocytic cells (mean ± standard error [SE]) was low or absent in BN (3.4 ± 1.4), increased significantly in DN (41.0 ± 10.1; P = .0003 for BN vs DN), and increased further in primary melanoma (119.9 ± 28.3; P = .06 for DN vs melanoma). MVD using CD31 (mean ± SE [percentage x intensity]) followed a similar pattern with similarity between BN (2.6 ± 0.7; N = 13) and DN (2.2 ± 0.8; N = 19; P = .4 for BN vs DN), whereas primary melanomas were significantly higher (39.4 ± 6.4; N = 17; P = .0001 for BN or DN vs melanoma). CONCLUSIONS. In a prospective setting, the current data suggested that increased VEGF-A expression in DN may be a good indicator of preneoplastic change in melanocytic lesions with the potential for improving the understanding and prevention of the transformation of DN to melanoma.

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KW - Dysplastic nevi

KW - Melanoma

KW - Microvessel density counts

KW - Vascular endothelial growth factor

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