Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits

Armando Geraldes, Teri Rambo, Rod A Wing, Nuno Ferrand, Michael W. Nachman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have remained nearly identical. This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome.

Original languageEnglish (US)
Pages (from-to)2437-2440
Number of pages4
JournalMolecular Biology and Evolution
Volume27
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

concerted evolution
Gene Conversion
gene conversion
Y chromosome
rabbits
Rabbits
gene
Y Chromosome
chromosome
Genes
genes
Oryctolagus cuniculus
Chromosomes, Human, Y
Mammalian Chromosomes
loci
gender
subspecies

Keywords

  • gene conversion
  • Oryctolagus cuniculus
  • SRY
  • Y chromosome

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits. / Geraldes, Armando; Rambo, Teri; Wing, Rod A; Ferrand, Nuno; Nachman, Michael W.

In: Molecular Biology and Evolution, Vol. 27, No. 11, 11.2010, p. 2437-2440.

Research output: Contribution to journalArticle

Geraldes, Armando ; Rambo, Teri ; Wing, Rod A ; Ferrand, Nuno ; Nachman, Michael W. / Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits. In: Molecular Biology and Evolution. 2010 ; Vol. 27, No. 11. pp. 2437-2440.
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