Extramammary Paget's Disease of the Vulva

David A. Fishman, Setsuko K Chambers, Peter E. Schwartz, Ernest I. Kohorn, Joseph T. Chambers

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Fourteen patients with extramammary Paget's disease of the vulva treated at Yale-New Haven Medical Center from 1982 through 1993 were reviewed to evaluate the accuracy of methods used to delineate surgical margins and to determine if radical operations or surgical margin status was associated with likelihood of recurrence. These 14 patients underwent at total of 25 operations for extramammary Paget's disease. In 8 operations, a total of 44 separate frozen-section biopsies were performed to determine extent of disease with a mean of 5.5 biopsies per patient. Visual judgment alone was used to determine margin status in 17 operations. The ability to delineate free surgical margins on permanent sections was not different, whether judged visually or by frozen-section analysis. Frozen-section analysis was misleading in 3/8 (37.5%) cases, while visual judgment was in error in 6/17 (35%) cases. Moreover, permanent margin status was not found to be predictive of disease recurrence. Two of 5 (40%) patients with positive margins recurred after initial surgery compared with 3 of 9 (33%) patients with negative margins. Of the 14 primary operations, there were 8 wide local excisions, 3 simple vulvectomies, and 3 modified radical vulvectomies. The radicality of the operation as initial treatment did not statistically correlate with disease recurrence.

Original languageEnglish (US)
Pages (from-to)266-270
Number of pages5
JournalGynecologic Oncology
Volume56
Issue number2
DOIs
StatePublished - Feb 1995
Externally publishedYes

Fingerprint

Extramammary Paget's Disease
Vulva
Frozen Sections
Recurrence
Biopsy
Aptitude
Margins of Excision

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Fishman, D. A., Chambers, S. K., Schwartz, P. E., Kohorn, E. I., & Chambers, J. T. (1995). Extramammary Paget's Disease of the Vulva. Gynecologic Oncology, 56(2), 266-270. https://doi.org/10.1006/gyno.1995.1044

Extramammary Paget's Disease of the Vulva. / Fishman, David A.; Chambers, Setsuko K; Schwartz, Peter E.; Kohorn, Ernest I.; Chambers, Joseph T.

In: Gynecologic Oncology, Vol. 56, No. 2, 02.1995, p. 266-270.

Research output: Contribution to journalArticle

Fishman, DA, Chambers, SK, Schwartz, PE, Kohorn, EI & Chambers, JT 1995, 'Extramammary Paget's Disease of the Vulva', Gynecologic Oncology, vol. 56, no. 2, pp. 266-270. https://doi.org/10.1006/gyno.1995.1044
Fishman DA, Chambers SK, Schwartz PE, Kohorn EI, Chambers JT. Extramammary Paget's Disease of the Vulva. Gynecologic Oncology. 1995 Feb;56(2):266-270. https://doi.org/10.1006/gyno.1995.1044
Fishman, David A. ; Chambers, Setsuko K ; Schwartz, Peter E. ; Kohorn, Ernest I. ; Chambers, Joseph T. / Extramammary Paget's Disease of the Vulva. In: Gynecologic Oncology. 1995 ; Vol. 56, No. 2. pp. 266-270.
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