Extramedullary breast relapse of acute lymphoblastic leukemia controlled with a second allogeneic/autologous hematopoietic cell transplant

Amy B. Houghtelin, Lisa M Kopp, Luz Pelayo-Katsanis, Phillip H Kuo, Andrew M Yeager, Emmanuel Katsanis

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Relapse of acute lymphoblastic leukemia (ALL) in the breast is uncommon and often precedes systemic relapse, resulting in poor survival. We report the development of breast involvement of ALL in a 20-year-old woman 32 months after a related allogeneic peripheral blood hematopoietic cell transplantation (PBHCT) in first remission. This extramedullary relapse occurred in the continuous presence of complete donor chimerism. After systemic re-induction chemotherapy and a second PBHCT using donor cells that had been cryopreserved at first transplant, our patient has remained in second complete remission for more than 44 months.

Original languageEnglish (US)
Pages (from-to)50-53
Number of pages4
JournalJournal of Adolescent and Young Adult Oncology
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2015

Keywords

  • Acute lymphoblastic leukemia
  • Allogeneic peripheral blood stem cell transplant
  • Extramedullary breast relapse
  • Graft-versus-host disease

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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