Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines

Zhigang Xu, Arthur Y. Shaw, Justin Dietrich, Alexandra P. Cappelli, Gary Nichol, Christopher Hulme

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Three scaffolds of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines were synthesized via Ugi/de-protection/ cyclization methodology. Benzimidazole forming ring closure was enabled under microwave irradiation in the presence of 10% TFA/DCE. The methodology demonstrates the utility of 2-(N-Boc-amino)-phenyl-isocyanide for the generation of new molecular diversity.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalMolecular Diversity
Volume16
Issue number1
DOIs
StatePublished - Feb 1 2012

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Keywords

  • Benzimidazoles
  • Bis-benzimidazole-dihydroquinoxalines
  • Bis-benzimidazoles
  • Multi-component reactions (MCRs)
  • UDC

ASJC Scopus subject areas

  • Catalysis
  • Information Systems
  • Molecular Biology
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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