Factors affecting insulin-like growth factor-I concentration in bovine milk.

Robert J Collier, M. A. Miller, J. R. Hildebrandt, A. R. Torkelson, T. C. White, K. S. Madsen, J. L. Vicini, P. J. Eppard, G. M. Lanza

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Abstract

To establish the naturally occurring range of insulin-like growth factor-I concentrations in bovine milk, samples from individual cows (n = 409) managed on five Missouri dairy herds were assayed. Parity, stage of lactation, and farm affected milk insulin-like growth factor-I concentration. Milk insulin-like growth factor-I concentration was higher in early lactation than mid and late lactation with concentrations in multiparous cows exceeding those in primiparous cows. Insulin-like growth factor-I concentration was negatively correlated to milk production the day of sample collection (r = -.15) and not correlated to predicted 305-d milk yields. Unprocessed bulk tank milk samples (n = 100) from a commercial processing plant had a mean concentration of insulin-like growth factor-I in milk of 4.32 ng/ml with a range of 1.27 to 8.10 ng/ml. This distribution was similar to the range detected in samples from individual cows, but values were lower than those reported for human milk. Concentration of insulin-like growth factor-I in milk was not altered by pasteurization (at 79 degrees C for 45 s). However, insulin-like growth factor-I was undetectable in milk heated to temperatures (121 degrees C for 5 min) required for infant formula preparation or in commercially available infant formula. These data indicated that insulin-like growth factor-I is a normal but quantitatively variable component of bovine milk that is not destroyed by pasteurization but is undetectable in infant formula. Concentration of insulin-like growth factor-I in bovine milk is lower than concentrations reported for human milk yet similar to those reported for human saliva.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)2905-2911
Number of pages7
JournalJournal of Dairy Science
Volume74
Issue number9
Publication statusPublished - Sep 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • veterinary(all)

Cite this

Collier, R. J., Miller, M. A., Hildebrandt, J. R., Torkelson, A. R., White, T. C., Madsen, K. S., ... Lanza, G. M. (1991). Factors affecting insulin-like growth factor-I concentration in bovine milk. Journal of Dairy Science, 74(9), 2905-2911.