Factors affecting insulin-like growth factor-I concentration in bovine milk.

Robert J Collier, M. A. Miller, J. R. Hildebrandt, A. R. Torkelson, T. C. White, K. S. Madsen, J. L. Vicini, P. J. Eppard, G. M. Lanza

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Abstract

To establish the naturally occurring range of insulin-like growth factor-I concentrations in bovine milk, samples from individual cows (n = 409) managed on five Missouri dairy herds were assayed. Parity, stage of lactation, and farm affected milk insulin-like growth factor-I concentration. Milk insulin-like growth factor-I concentration was higher in early lactation than mid and late lactation with concentrations in multiparous cows exceeding those in primiparous cows. Insulin-like growth factor-I concentration was negatively correlated to milk production the day of sample collection (r = -.15) and not correlated to predicted 305-d milk yields. Unprocessed bulk tank milk samples (n = 100) from a commercial processing plant had a mean concentration of insulin-like growth factor-I in milk of 4.32 ng/ml with a range of 1.27 to 8.10 ng/ml. This distribution was similar to the range detected in samples from individual cows, but values were lower than those reported for human milk. Concentration of insulin-like growth factor-I in milk was not altered by pasteurization (at 79 degrees C for 45 s). However, insulin-like growth factor-I was undetectable in milk heated to temperatures (121 degrees C for 5 min) required for infant formula preparation or in commercially available infant formula. These data indicated that insulin-like growth factor-I is a normal but quantitatively variable component of bovine milk that is not destroyed by pasteurization but is undetectable in infant formula. Concentration of insulin-like growth factor-I in bovine milk is lower than concentrations reported for human milk yet similar to those reported for human saliva.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)2905-2911
Number of pages7
JournalJournal of Dairy Science
Volume74
Issue number9
StatePublished - Sep 1991
Externally publishedYes

Fingerprint

insulin-like growth factor I
Insulin-Like Growth Factor I
Milk
milk
Infant Formula
infant formulas
Lactation
Pasteurization
cows
Human Milk
pasteurization
breast milk
Transforming Growth Factor beta
sampling
milk tanks
late lactation
lactation stage
early lactation
Parity
saliva

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • veterinary(all)

Cite this

Collier, R. J., Miller, M. A., Hildebrandt, J. R., Torkelson, A. R., White, T. C., Madsen, K. S., ... Lanza, G. M. (1991). Factors affecting insulin-like growth factor-I concentration in bovine milk. Journal of Dairy Science, 74(9), 2905-2911.

Factors affecting insulin-like growth factor-I concentration in bovine milk. / Collier, Robert J; Miller, M. A.; Hildebrandt, J. R.; Torkelson, A. R.; White, T. C.; Madsen, K. S.; Vicini, J. L.; Eppard, P. J.; Lanza, G. M.

In: Journal of Dairy Science, Vol. 74, No. 9, 09.1991, p. 2905-2911.

Research output: Contribution to journalArticle

Collier, RJ, Miller, MA, Hildebrandt, JR, Torkelson, AR, White, TC, Madsen, KS, Vicini, JL, Eppard, PJ & Lanza, GM 1991, 'Factors affecting insulin-like growth factor-I concentration in bovine milk.', Journal of Dairy Science, vol. 74, no. 9, pp. 2905-2911.
Collier RJ, Miller MA, Hildebrandt JR, Torkelson AR, White TC, Madsen KS et al. Factors affecting insulin-like growth factor-I concentration in bovine milk. Journal of Dairy Science. 1991 Sep;74(9):2905-2911.
Collier, Robert J ; Miller, M. A. ; Hildebrandt, J. R. ; Torkelson, A. R. ; White, T. C. ; Madsen, K. S. ; Vicini, J. L. ; Eppard, P. J. ; Lanza, G. M. / Factors affecting insulin-like growth factor-I concentration in bovine milk. In: Journal of Dairy Science. 1991 ; Vol. 74, No. 9. pp. 2905-2911.
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