Factors related to length of complete remission in adult acute leukemia

M. J. Keating, T. L. Smith, E. A. Gehan, K. B. McCredie, G. P. Bodey, G. Spitzer, E. Hersh, J. Gutterman, E. J. Freireich

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Two hundred and two adult patients with acute leukemia were analyzed to determine pretreatment and treatment factors that could predict for duration of bone marrow remission. Several factors had a significant effect on remission duration, including morphologic diagnosis (AML > ALL > AUL), initial blast cell count, age, serum LDH, fibrinogen level, labeling index, and in vitro agar colony growth. Patients who attained a remission quickly or in whom leukemic cells in blood and bone marrow were rapidly cleared had long remissions. After applying regression model fitting methods, the six major factors, in order of significance, were the initial serum LDH level, pretreatment fibrinogen level, the number of courses of treatment to obtain a remission, morphologic diagnosis, the halving rate of leukemic cells in the blood, and the age of the patient. The model derived from this study was applied to the 202 patients and suggested that patients likely to have short or long bone marrow remission can be identified.

Original languageEnglish (US)
Pages (from-to)2017-2029
Number of pages13
JournalCancer
Volume45
Issue number8
DOIs
StatePublished - Apr 15 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Keating, M. J., Smith, T. L., Gehan, E. A., McCredie, K. B., Bodey, G. P., Spitzer, G., Hersh, E., Gutterman, J., & Freireich, E. J. (1980). Factors related to length of complete remission in adult acute leukemia. Cancer, 45(8), 2017-2029. https://doi.org/10.1002/1097-0142(19800415)45:8<2017::AID-CNCR2820450806>3.0.CO;2-C