Failure of acute hypoxia to alter pulmonary prostaglandin metabolism in dogs

Mary A. Moon, Richard J. Lemen, Stuart F Quan

Research output: Contribution to journalArticle

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Abstract

We studied the effects of acute hypoxia (Fi02=0.09-0.11, 20 min,.) on transpulmonary plasma prostaglandin (PG) concentrations in ten anaesthetized, paralyzed, artificially ventilated dogs. Concentrations of 6-keto-PGF1α, TxB2, PGE2, PGF2α, and 13, 13-dihydro-15-keto-PGF2α were measured from the pulmonary artery and abdominal aorta using radioimmunoassay. In an additional six dogs, the effects of arachidonic acid (AA) infusions (100 mg/kg/min) during normoxia and acute hypoxia were determined. Compared to normoxic conditions, acute hypoxia increased pulmonary artery pressure (p<0.0), decreased both the arterial oxygen tension (Pa02) and the alveolar-to-arterial oxygen tension gradient (A-aD02) (p <0.05), but did not affect transpulmonary plasma PG concentrations. AA infusions significantly (p <0.05) increased 6-keto-PGF1α independent of Fi02. Acute hypoxia failed to elicit a pulmonary pressor response in the AA-treated animals although Pa02 and A-aD02 decreased (p<0.5). These data in healthy dogs suggest that (1) acute hypoxia does not alter net pulmonary PG metabolism, (2) prostacyclin synthesis is stimulated by increased plasma AA concentrations and (3) this effect may block normal pressor responses to hypoxic stimuli.

Original languageEnglish (US)
Pages (from-to)615-627
Number of pages13
JournalProstaglandins
Volume25
Issue number5
DOIs
StatePublished - 1983

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Arachidonic Acid
Metabolism
Prostaglandins
Dogs
Lung
Dinoprost
Plasmas
Pulmonary Artery
Oxygen
Arterial Pressure
Epoprostenol
Dinoprostone
Abdominal Aorta
Animals
Radioimmunoassay
Hypoxia
Pressure
prostaglandin F1

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Failure of acute hypoxia to alter pulmonary prostaglandin metabolism in dogs. / Moon, Mary A.; Lemen, Richard J.; Quan, Stuart F.

In: Prostaglandins, Vol. 25, No. 5, 1983, p. 615-627.

Research output: Contribution to journalArticle

Moon, Mary A. ; Lemen, Richard J. ; Quan, Stuart F. / Failure of acute hypoxia to alter pulmonary prostaglandin metabolism in dogs. In: Prostaglandins. 1983 ; Vol. 25, No. 5. pp. 615-627.
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