Failure of intravenous metoprolol to limit acute myocardial infarct size in a nonreperfused porcine model

Karl B. Kern, Ronald W. Hilwig, Alberta Warner, Michael Basnight, Gordon A. Ewy

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The usefulness of intravenous β-adrenergic receptor blockade in limiting infarct size when neither reperfusion nor collateral flow occurs is unknown. The effect of intravenous metoprolol on limiting myocardial infarct size was therefore examined in a nonreperfused porcine model. Closed-chest techniques were used to occlude the left anterior descending coronary artery, after which animals were randomized at 20 minutes to receive intravenous metoprolol, 0.75 mg/kg, or placebo. Infarct size examined at 5 hours with Evans blue and triphenyltetrazolium ataining techniques was expressed as a percentage of total ventricular myocardium at ischemic risk. This percentage was not significantly different between the groups (84% ± 5% with metoprolol vs 90% ± 4% with placebo; p = 0.4). Myocardial infarct size was not significantly decreased at 5 hours by early administration of intravenous metoprolol when the infarct artery remained occluded and collateral flow was minimal.

Original languageEnglish (US)
Pages (from-to)650-655
Number of pages6
JournalAmerican Heart Journal
Volume129
Issue number4
DOIs
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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