Fallopian tube secretory cell expansion

A sensitive biomarker for ovarian serous carcinogenesis

Yiying Wang, Li Li, Yue Wang, Sarah Ngocvi Tang, Wenxin - Zheng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recent advances suggest that precancerous lesions of pelvic serous carcinoma originate from tubal secretory cells. The purpose of our study was to determine if an increased number of secretory cells vary with age or location in the fallopian tube and to examine its association with serous neoplasia. Three groups (benign control, high-risk, and pelvic serous carcinoma) of age-matched patients were studied. The age data were stratified into 10-year intervals ranging from 20-29 to older than 80. The number of secretory and ciliated cells from both tubal fimbria and ampulla segments was counted by microscopy and immunohistochemical staining methods. The data were analyzed by standard contingency table and Poisson distribution methods after age justification. We found that the absolute number of tubal secretory cells increased significantly with age in all three groups. But a more dramatic increase of secretory cells was observed in high-risk and pelvic serous carcinoma patients. Secretory cell expansion is more prevalent than secretory cell outgrowth in both fimbria and ampulla tubal segments and is significantly associated with serous neoplasia (p <0.001). Furthermore, age remained a significant risk factor for serous neoplasia after age adjustment. These findings suggest that secretory cell expansion could serve as a potential sensitive biomarker for early serous carcinogenesis within the fallopian tube. The study also supports a relationship between serous neoplasia and increased secretory to ciliated cell ratios, and the relationship between frequency of secretory cell expansion within the fallopian tube and increasing age and-more significantly-presence of high-risk factors or co-existing serous cancers.

Original languageEnglish (US)
Pages (from-to)230-238
Number of pages9
JournalAmerican Journal of Translational Research
Volume8
Issue number1
StatePublished - 2016

Fingerprint

Fallopian Tubes
Biomarkers
Carcinogenesis
Poisson distribution
Neoplasms
Carcinoma
Microscopic examination
Association reactions
Poisson Distribution
Microscopy
Cell Count
Staining and Labeling
Control Groups

Keywords

  • Carcinogenesis
  • Fallopian tube
  • Ovarian cancer
  • Pathogenesis
  • Pelvic serous carcinoma
  • Tubal secretory cells

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Fallopian tube secretory cell expansion : A sensitive biomarker for ovarian serous carcinogenesis. / Wang, Yiying; Li, Li; Wang, Yue; Tang, Sarah Ngocvi; Zheng, Wenxin -.

In: American Journal of Translational Research, Vol. 8, No. 1, 2016, p. 230-238.

Research output: Contribution to journalArticle

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