Abstract
Dopamine transporter SPECT is an accurate adjunct to clinical evaluation for Parkinson disease when the diagnosis is difficult. Dopaminergic medications may significantly affect dopamine transporter availability and, thus, uptake of dopamine transporter tracers. A patient had a false-positive dopamine transporter SPECT result while she was taking dextroamphetamine and amphetamine for attention-deficit hyperactivity disorder. The SPECT findings normalized after amphetamine therapy was withheld. An accurate medication history combined with knowledge of drugs that interfere with dopamine transporter imaging is critical to ensure accuracy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 149-150 |
| Number of pages | 2 |
| Journal | Journal of Nuclear Medicine Technology |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2018 |
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Keywords
- Amphetamine
- Dopamine transporter
- Ioflupane
- Parkinson disease
- Single-photon positron emission tomography
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
Cite this
False-positive findings on dopamine transporter SPECT due to therapeutic dextroamphetamine and amphetamine. / Frankl, Joseph A.; Bose, Sudeshna C; Kuo, Phillip H.
In: Journal of Nuclear Medicine Technology, Vol. 46, No. 2, 01.06.2018, p. 149-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - False-positive findings on dopamine transporter SPECT due to therapeutic dextroamphetamine and amphetamine
AU - Frankl, Joseph A.
AU - Bose, Sudeshna C
AU - Kuo, Phillip H
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Dopamine transporter SPECT is an accurate adjunct to clinical evaluation for Parkinson disease when the diagnosis is difficult. Dopaminergic medications may significantly affect dopamine transporter availability and, thus, uptake of dopamine transporter tracers. A patient had a false-positive dopamine transporter SPECT result while she was taking dextroamphetamine and amphetamine for attention-deficit hyperactivity disorder. The SPECT findings normalized after amphetamine therapy was withheld. An accurate medication history combined with knowledge of drugs that interfere with dopamine transporter imaging is critical to ensure accuracy.
AB - Dopamine transporter SPECT is an accurate adjunct to clinical evaluation for Parkinson disease when the diagnosis is difficult. Dopaminergic medications may significantly affect dopamine transporter availability and, thus, uptake of dopamine transporter tracers. A patient had a false-positive dopamine transporter SPECT result while she was taking dextroamphetamine and amphetamine for attention-deficit hyperactivity disorder. The SPECT findings normalized after amphetamine therapy was withheld. An accurate medication history combined with knowledge of drugs that interfere with dopamine transporter imaging is critical to ensure accuracy.
KW - Amphetamine
KW - Dopamine transporter
KW - Ioflupane
KW - Parkinson disease
KW - Single-photon positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=85048125147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048125147&partnerID=8YFLogxK
U2 - 10.2967/jnmt.117.201558
DO - 10.2967/jnmt.117.201558
M3 - Article
VL - 46
SP - 149
EP - 150
JO - Journal of Nuclear Medicine Technology
JF - Journal of Nuclear Medicine Technology
SN - 0091-4916
IS - 2
ER -