False-positive findings on dopamine transporter SPECT due to therapeutic dextroamphetamine and amphetamine

Joseph A. Frankl, Sudeshna C Bose, Phillip H Kuo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Dopamine transporter SPECT is an accurate adjunct to clinical evaluation for Parkinson disease when the diagnosis is difficult. Dopaminergic medications may significantly affect dopamine transporter availability and, thus, uptake of dopamine transporter tracers. A patient had a false-positive dopamine transporter SPECT result while she was taking dextroamphetamine and amphetamine for attention-deficit hyperactivity disorder. The SPECT findings normalized after amphetamine therapy was withheld. An accurate medication history combined with knowledge of drugs that interfere with dopamine transporter imaging is critical to ensure accuracy.

Original languageEnglish (US)
Pages (from-to)149-150
Number of pages2
JournalJournal of Nuclear Medicine Technology
Volume46
Issue number2
DOIs
StatePublished - Jun 1 2018

Fingerprint

Dextroamphetamine
Dopamine Plasma Membrane Transport Proteins
Amphetamine
Single-Photon Emission-Computed Tomography
Therapeutics
Attention Deficit Disorder with Hyperactivity
Parkinson Disease
Pharmaceutical Preparations

Keywords

  • Amphetamine
  • Dopamine transporter
  • Ioflupane
  • Parkinson disease
  • Single-photon positron emission tomography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

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AB - Dopamine transporter SPECT is an accurate adjunct to clinical evaluation for Parkinson disease when the diagnosis is difficult. Dopaminergic medications may significantly affect dopamine transporter availability and, thus, uptake of dopamine transporter tracers. A patient had a false-positive dopamine transporter SPECT result while she was taking dextroamphetamine and amphetamine for attention-deficit hyperactivity disorder. The SPECT findings normalized after amphetamine therapy was withheld. An accurate medication history combined with knowledge of drugs that interfere with dopamine transporter imaging is critical to ensure accuracy.

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