Familial aggregation of allergen-specific sensitization and asthma

Margaret Kurzius-Spencer, Stefano Guerra, Duane L Sherrill, Marilyn Halonen, Robert C. Elston, Fernando Martinez

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Familial aggregation of specific response to allergens and asthma adjusted for age and sensitization to multiple allergens was assessed in two large population cohorts. Methods: Allergen skin prick tests (SPTs) were administered to 1151 families in the Tucson Children's Respiratory Study (CRS) and 435 families in the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD). Sensitization was defined by wheal size ≥3mm; physician-diagnosed asthma at age ≥8yr was based on questionnaires. Using s.a.g.e. 6.1 software assoc and fcor, familial correlations of crude and adjusted phenotypes were evaluated. Results: Crude estimates of parent-offspring (P-O) and sibling correlations were statistically significant for most allergens, ranging from 0.03 to 0.29. After adjusting for age of assessment and 'other atopy' (SPT-positive response to additional allergens), correlations were reduced by 14-71%. Sibling correlations for specific response to allergens were consistently higher than P-O correlations, but this difference was significant only for dust mite and weed mix in the TESAOD population. Familial correlation for atopic status (any positive SPTs vs. none) tended to be higher than for specific allergens. Asthma, with and without adjustment, showed greater familial correlation than either specific or general SPT response and significantly higher sibling correlation in TESAOD than in CRS, probably due to the older age of the siblings and the longer period of ascertainment. Conclusions: Significant familial aggregation of specific response to allergen after adjustment for other atopy appears to reflect a genetic propensity toward atopy, dependent on shared familial exposures. Results also suggest that inheritance of asthma is independent of atopic sensitization.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalPediatric Allergy and Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 2012

Fingerprint

Allergens
Asthma
Skin Tests
Siblings
Epidemiologic Studies
Social Adjustment
Mites
Dust
Population
Software
Physicians
Phenotype

Keywords

  • Asthma
  • Atopy
  • Familial aggregation
  • Specific response to allergens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

Cite this

Familial aggregation of allergen-specific sensitization and asthma. / Kurzius-Spencer, Margaret; Guerra, Stefano; Sherrill, Duane L; Halonen, Marilyn; Elston, Robert C.; Martinez, Fernando.

In: Pediatric Allergy and Immunology, Vol. 23, No. 1, 02.2012, p. 21-27.

Research output: Contribution to journalArticle

@article{2126ef8a0d5e407392a378228a61c7ba,
title = "Familial aggregation of allergen-specific sensitization and asthma",
abstract = "Background: Familial aggregation of specific response to allergens and asthma adjusted for age and sensitization to multiple allergens was assessed in two large population cohorts. Methods: Allergen skin prick tests (SPTs) were administered to 1151 families in the Tucson Children's Respiratory Study (CRS) and 435 families in the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD). Sensitization was defined by wheal size ≥3mm; physician-diagnosed asthma at age ≥8yr was based on questionnaires. Using s.a.g.e. 6.1 software assoc and fcor, familial correlations of crude and adjusted phenotypes were evaluated. Results: Crude estimates of parent-offspring (P-O) and sibling correlations were statistically significant for most allergens, ranging from 0.03 to 0.29. After adjusting for age of assessment and 'other atopy' (SPT-positive response to additional allergens), correlations were reduced by 14-71{\%}. Sibling correlations for specific response to allergens were consistently higher than P-O correlations, but this difference was significant only for dust mite and weed mix in the TESAOD population. Familial correlation for atopic status (any positive SPTs vs. none) tended to be higher than for specific allergens. Asthma, with and without adjustment, showed greater familial correlation than either specific or general SPT response and significantly higher sibling correlation in TESAOD than in CRS, probably due to the older age of the siblings and the longer period of ascertainment. Conclusions: Significant familial aggregation of specific response to allergen after adjustment for other atopy appears to reflect a genetic propensity toward atopy, dependent on shared familial exposures. Results also suggest that inheritance of asthma is independent of atopic sensitization.",
keywords = "Asthma, Atopy, Familial aggregation, Specific response to allergens",
author = "Margaret Kurzius-Spencer and Stefano Guerra and Sherrill, {Duane L} and Marilyn Halonen and Elston, {Robert C.} and Fernando Martinez",
year = "2012",
month = "2",
doi = "10.1111/j.1399-3038.2011.01220.x",
language = "English (US)",
volume = "23",
pages = "21--27",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "1",

}

TY - JOUR

T1 - Familial aggregation of allergen-specific sensitization and asthma

AU - Kurzius-Spencer, Margaret

AU - Guerra, Stefano

AU - Sherrill, Duane L

AU - Halonen, Marilyn

AU - Elston, Robert C.

AU - Martinez, Fernando

PY - 2012/2

Y1 - 2012/2

N2 - Background: Familial aggregation of specific response to allergens and asthma adjusted for age and sensitization to multiple allergens was assessed in two large population cohorts. Methods: Allergen skin prick tests (SPTs) were administered to 1151 families in the Tucson Children's Respiratory Study (CRS) and 435 families in the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD). Sensitization was defined by wheal size ≥3mm; physician-diagnosed asthma at age ≥8yr was based on questionnaires. Using s.a.g.e. 6.1 software assoc and fcor, familial correlations of crude and adjusted phenotypes were evaluated. Results: Crude estimates of parent-offspring (P-O) and sibling correlations were statistically significant for most allergens, ranging from 0.03 to 0.29. After adjusting for age of assessment and 'other atopy' (SPT-positive response to additional allergens), correlations were reduced by 14-71%. Sibling correlations for specific response to allergens were consistently higher than P-O correlations, but this difference was significant only for dust mite and weed mix in the TESAOD population. Familial correlation for atopic status (any positive SPTs vs. none) tended to be higher than for specific allergens. Asthma, with and without adjustment, showed greater familial correlation than either specific or general SPT response and significantly higher sibling correlation in TESAOD than in CRS, probably due to the older age of the siblings and the longer period of ascertainment. Conclusions: Significant familial aggregation of specific response to allergen after adjustment for other atopy appears to reflect a genetic propensity toward atopy, dependent on shared familial exposures. Results also suggest that inheritance of asthma is independent of atopic sensitization.

AB - Background: Familial aggregation of specific response to allergens and asthma adjusted for age and sensitization to multiple allergens was assessed in two large population cohorts. Methods: Allergen skin prick tests (SPTs) were administered to 1151 families in the Tucson Children's Respiratory Study (CRS) and 435 families in the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD). Sensitization was defined by wheal size ≥3mm; physician-diagnosed asthma at age ≥8yr was based on questionnaires. Using s.a.g.e. 6.1 software assoc and fcor, familial correlations of crude and adjusted phenotypes were evaluated. Results: Crude estimates of parent-offspring (P-O) and sibling correlations were statistically significant for most allergens, ranging from 0.03 to 0.29. After adjusting for age of assessment and 'other atopy' (SPT-positive response to additional allergens), correlations were reduced by 14-71%. Sibling correlations for specific response to allergens were consistently higher than P-O correlations, but this difference was significant only for dust mite and weed mix in the TESAOD population. Familial correlation for atopic status (any positive SPTs vs. none) tended to be higher than for specific allergens. Asthma, with and without adjustment, showed greater familial correlation than either specific or general SPT response and significantly higher sibling correlation in TESAOD than in CRS, probably due to the older age of the siblings and the longer period of ascertainment. Conclusions: Significant familial aggregation of specific response to allergen after adjustment for other atopy appears to reflect a genetic propensity toward atopy, dependent on shared familial exposures. Results also suggest that inheritance of asthma is independent of atopic sensitization.

KW - Asthma

KW - Atopy

KW - Familial aggregation

KW - Specific response to allergens

UR - http://www.scopus.com/inward/record.url?scp=84856399410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856399410&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3038.2011.01220.x

DO - 10.1111/j.1399-3038.2011.01220.x

M3 - Article

C2 - 22017397

AN - SCOPUS:84856399410

VL - 23

SP - 21

EP - 27

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 1

ER -