Familial aggregation of sinonasal polyps correlates with severity of disease

Noam A. Cohen, Jeffrey S. Widelitz, Alexander G. Chiu, James N. Palmer, David W. Kennedy

Research output: Contribution to journalArticle

46 Scopus citations


OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM rating: B-2b

Original languageEnglish (US)
Pages (from-to)601-604
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Issue number4
StatePublished - Apr 1 2006


ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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