Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors

Joshua S. Talboom, Asta Håberg, Matthew D. De Both, Marcus A. Naymik, Isabelle Schrauwen, Candace R. Lewis, Stacy F. Bertinelli, Callie Hammersland, Mason A. Fritz, Amanda J. Myers, Meredith Hay, Carol A Barnes, Elizabeth L Glisky, T Lee Ryan, Matthew J. Huentelman

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer's disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18-85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified.

Original languageEnglish (US)
JournaleLife
Volume8
DOIs
StatePublished - Jun 18 2019

Keywords

  • Alzheimer's Disease
  • Apolipoprotein E (APOE)
  • dementia
  • family history
  • human
  • human biology
  • internet-based
  • medicine
  • neuroscience
  • paired-associates learning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Talboom, J. S., Håberg, A., De Both, M. D., Naymik, M. A., Schrauwen, I., Lewis, C. R., Bertinelli, S. F., Hammersland, C., Fritz, M. A., Myers, A. J., Hay, M., Barnes, C. A., Glisky, E. L., Ryan, T. L., & Huentelman, M. J. (2019). Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors. eLife, 8. https://doi.org/10.7554/eLife.46179