Family history of coronary heart disease and hemostatic variables in middle-aged adults

James S. Pankow, Aaron R. Folsom, Michael A. Province, D. C. Rao, John Eckfeldt, Gerardo Heiss, Eyal Shahar, Kenneth K. Wu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Individuals with a family history of coronary heart disease (CHD) may be predisposed to atherothrombosis. To investigate this hypothesis, a family CHD risk score was computed for approximately 13,000 men and women aged 45 to 64; hemostatic variables (fibrinogen, factor VIIc, factor VIIIC, von Willebrand factor, antithrombin III, protein C) were also measured in plasma. After adjustment for age and ethnicity, there was a statistically significant, positive association between the family risk score and four of the six hemostatic variables (fibrinogen, factor VIIc, factor VIIIc, von Willebrand factor) in women and all six hemostatic variables in men. In general, these associations were weak and substantially attenuated after adjustment for constitutional, lifestyle, and biochemical covariates. These results indicate that mean levels of selected hemostatic variables, like traditional CHD risk factors, are higher in individuals with a family history of heart disease.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalThrombosis and Haemostasis
Volume77
Issue number1
StatePublished - Jan 1997
Externally publishedYes

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Hemostatics
Coronary Disease
von Willebrand Factor
Fibrinogen
Antithrombin Proteins
Antithrombin III
Factor VIII
Protein C
Life Style
Heart Diseases

ASJC Scopus subject areas

  • Hematology

Cite this

Pankow, J. S., Folsom, A. R., Province, M. A., Rao, D. C., Eckfeldt, J., Heiss, G., ... Wu, K. K. (1997). Family history of coronary heart disease and hemostatic variables in middle-aged adults. Thrombosis and Haemostasis, 77(1), 87-93.

Family history of coronary heart disease and hemostatic variables in middle-aged adults. / Pankow, James S.; Folsom, Aaron R.; Province, Michael A.; Rao, D. C.; Eckfeldt, John; Heiss, Gerardo; Shahar, Eyal; Wu, Kenneth K.

In: Thrombosis and Haemostasis, Vol. 77, No. 1, 01.1997, p. 87-93.

Research output: Contribution to journalArticle

Pankow, JS, Folsom, AR, Province, MA, Rao, DC, Eckfeldt, J, Heiss, G, Shahar, E & Wu, KK 1997, 'Family history of coronary heart disease and hemostatic variables in middle-aged adults', Thrombosis and Haemostasis, vol. 77, no. 1, pp. 87-93.
Pankow JS, Folsom AR, Province MA, Rao DC, Eckfeldt J, Heiss G et al. Family history of coronary heart disease and hemostatic variables in middle-aged adults. Thrombosis and Haemostasis. 1997 Jan;77(1):87-93.
Pankow, James S. ; Folsom, Aaron R. ; Province, Michael A. ; Rao, D. C. ; Eckfeldt, John ; Heiss, Gerardo ; Shahar, Eyal ; Wu, Kenneth K. / Family history of coronary heart disease and hemostatic variables in middle-aged adults. In: Thrombosis and Haemostasis. 1997 ; Vol. 77, No. 1. pp. 87-93.
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