Family history of coronary heart disease and hemostatic variables in middle-aged adults

James S. Pankow, Aaron R. Folsom, Michael A. Province, D. C. Rao, John Eckfeldt, Gerardo Heiss, Eyal Shahar, Kenneth K. Wu

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Individuals with a family history of coronary heart disease (CHD) may be predisposed to atherothrombosis. To investigate this hypothesis, a family CHD risk score was computed for approximately 13,000 men and women aged 45 to 64; hemostatic variables (fibrinogen, factor VIIc, factor VIIIC, von Willebrand factor, antithrombin III, protein C) were also measured in plasma. After adjustment for age and ethnicity, there was a statistically significant, positive association between the family risk score and four of the six hemostatic variables (fibrinogen, factor VIIc, factor VIIIc, von Willebrand factor) in women and all six hemostatic variables in men. In general, these associations were weak and substantially attenuated after adjustment for constitutional, lifestyle, and biochemical covariates. These results indicate that mean levels of selected hemostatic variables, like traditional CHD risk factors, are higher in individuals with a family history of heart disease.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalThrombosis and Haemostasis
Volume77
Issue number1
DOIs
StatePublished - Jan 1997

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Family history of coronary heart disease and hemostatic variables in middle-aged adults'. Together they form a unique fingerprint.

Cite this