Farm living: Effects on childhood asthma and allergy

Erika Von Mutius, Donata Vercelli

Research output: Contribution to journalArticle

364 Citations (Scopus)

Abstract

Numerous epidemiological studies have shown that children who grow up on traditional farms are protected from asthma, hay fever and allergic sensitization. Early-life contact with livestock and their fodder, and consumption of unprocessed cow's milk have been identified as the most effective protective exposures. Studies of the immunobiology of farm living point to activation and modulation of innate and adaptive immune responses by intense microbial exposures and possibly xenogeneic signals delivered before or soon after birth.

Original languageEnglish (US)
Pages (from-to)861-868
Number of pages8
JournalNature Reviews Immunology
Volume10
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Hypersensitivity
Asthma
Seasonal Allergic Rhinitis
Livestock
Adaptive Immunity
Innate Immunity
Epidemiologic Studies
Milk
Parturition
Farms

ASJC Scopus subject areas

  • Immunology

Cite this

Farm living : Effects on childhood asthma and allergy. / Von Mutius, Erika; Vercelli, Donata.

In: Nature Reviews Immunology, Vol. 10, No. 12, 12.2010, p. 861-868.

Research output: Contribution to journalArticle

Von Mutius, Erika ; Vercelli, Donata. / Farm living : Effects on childhood asthma and allergy. In: Nature Reviews Immunology. 2010 ; Vol. 10, No. 12. pp. 861-868.
@article{007793e3482a4e78a8bb38a2b9c2ffbc,
title = "Farm living: Effects on childhood asthma and allergy",
abstract = "Numerous epidemiological studies have shown that children who grow up on traditional farms are protected from asthma, hay fever and allergic sensitization. Early-life contact with livestock and their fodder, and consumption of unprocessed cow's milk have been identified as the most effective protective exposures. Studies of the immunobiology of farm living point to activation and modulation of innate and adaptive immune responses by intense microbial exposures and possibly xenogeneic signals delivered before or soon after birth.",
author = "{Von Mutius}, Erika and Donata Vercelli",
year = "2010",
month = "12",
doi = "10.1038/nri2871",
language = "English (US)",
volume = "10",
pages = "861--868",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Farm living

T2 - Effects on childhood asthma and allergy

AU - Von Mutius, Erika

AU - Vercelli, Donata

PY - 2010/12

Y1 - 2010/12

N2 - Numerous epidemiological studies have shown that children who grow up on traditional farms are protected from asthma, hay fever and allergic sensitization. Early-life contact with livestock and their fodder, and consumption of unprocessed cow's milk have been identified as the most effective protective exposures. Studies of the immunobiology of farm living point to activation and modulation of innate and adaptive immune responses by intense microbial exposures and possibly xenogeneic signals delivered before or soon after birth.

AB - Numerous epidemiological studies have shown that children who grow up on traditional farms are protected from asthma, hay fever and allergic sensitization. Early-life contact with livestock and their fodder, and consumption of unprocessed cow's milk have been identified as the most effective protective exposures. Studies of the immunobiology of farm living point to activation and modulation of innate and adaptive immune responses by intense microbial exposures and possibly xenogeneic signals delivered before or soon after birth.

UR - http://www.scopus.com/inward/record.url?scp=78649512314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649512314&partnerID=8YFLogxK

U2 - 10.1038/nri2871

DO - 10.1038/nri2871

M3 - Article

C2 - 21060319

AN - SCOPUS:78649512314

VL - 10

SP - 861

EP - 868

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 12

ER -