Fas receptor expression on asthmatic eosinophils

Judith E. Fahy, Stuart F. Quan, John W. Bloom, Marilyn J. Halonen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Activation of the Fas receptor (Fas; CD95) on eosinophils induces apoptosis and may play a role in controlling eosinophil number in blood and tissue. To determine whether Fas expression on eosinophils is different between asthmatics and nonasthmatics, eosinophils were isolated from the peripheral blood using a three-step procedure of dextran sedimentation, ficoll hypaque separation and negative selection with anti-CD16 monoclonal antibody bound to magnetic beads. Fas expression was quantified by flow cytometry. Fas expression and the percentage of eosinophils expressing Fas were not different between asthmatics (n=9) and non-asthmatics (n=14).

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume102
Issue number1
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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