Fatal rhabdomyolysis as a complication of ET-743 (Yondelis) chemotherapy for sarcoma

Amy Skorupa, Matthew Beldner, Andrew Kraft, Alberto J. Montero

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Rhabdomyolysis is a clinical syndrome in which skeletal muscle damage and necrosis leads to the release of intracellular muscle contents, which can ultimately lead to electrolyte disturbances, renal failure and even death. Chemotherapy is an extremely rare cause of rhabdomyolysis. Herein, we describe a fatal case of rhabdomyolysis in a patient with metastatic sarcoma after receiving the chemotherapeutic agent Ecteinascidin-743 (ET-743, trabectedin) as palliative chemotherapy treatment.

Original languageEnglish (US)
Pages (from-to)1015-1017
Number of pages3
JournalCancer Biology and Therapy
Volume6
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

Keywords

  • Ecteinascidin-743 (Yondelis)
  • Rhabdomyolysis
  • Sarcoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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