Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept

Mercedeh Bachai, Douglas R. Osmon, Donna Wolk, Lester E. Wold, George J. Haidukewych, Eric L. Matteson

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Patients with long-standing, severe, erosive rheumatoid arthritis who have extra-articular manifestations and have undergone joint replacement surgery are at increased risk for serious infection and premature mortality. New therapies, including cytokine antagonists, hold great promise for improving the course of rheumatoid arthritis. However, they have powerful anti-inflammatory effects that may mask symptoms of serious infection. We report a case of fatal pneumococcal sepsis occurring in a 37-year-old woman with rheumatoid arthritis treated with the tumor necrosis factor antagonist etanercept and suggest management strategies for early detection and management of this complication.

Original languageEnglish (US)
Pages (from-to)653-656
Number of pages4
JournalMayo Clinic Proceedings
Volume76
Issue number6
StatePublished - 2001
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
Sepsis
Replacement Arthroplasties
Premature Mortality
Masks
Infection
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Joints
Cytokines
Etanercept
Therapeutics

Keywords

  • DMARD = disease-modifying antirheumatic drug
  • NSAID = nonsteroidal anti-inflammatory drug
  • RA = rheumatoid arthritis
  • WBC = white blood cell

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bachai, M., Osmon, D. R., Wolk, D., Wold, L. E., Haidukewych, G. J., & Matteson, E. L. (2001). Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept. Mayo Clinic Proceedings, 76(6), 653-656.

Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept. / Bachai, Mercedeh; Osmon, Douglas R.; Wolk, Donna; Wold, Lester E.; Haidukewych, George J.; Matteson, Eric L.

In: Mayo Clinic Proceedings, Vol. 76, No. 6, 2001, p. 653-656.

Research output: Contribution to journalArticle

Bachai, M, Osmon, DR, Wolk, D, Wold, LE, Haidukewych, GJ & Matteson, EL 2001, 'Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept', Mayo Clinic Proceedings, vol. 76, no. 6, pp. 653-656.
Bachai M, Osmon DR, Wolk D, Wold LE, Haidukewych GJ, Matteson EL. Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept. Mayo Clinic Proceedings. 2001;76(6):653-656.
Bachai, Mercedeh ; Osmon, Douglas R. ; Wolk, Donna ; Wold, Lester E. ; Haidukewych, George J. ; Matteson, Eric L. / Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept. In: Mayo Clinic Proceedings. 2001 ; Vol. 76, No. 6. pp. 653-656.
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