Abstract
Patients with long-standing, severe, erosive rheumatoid arthritis who have extra-articular manifestations and have undergone joint replacement surgery are at increased risk for serious infection and premature mortality. New therapies, including cytokine antagonists, hold great promise for improving the course of rheumatoid arthritis. However, they have powerful anti-inflammatory effects that may mask symptoms of serious infection. We report a case of fatal pneumococcal sepsis occurring in a 37-year-old woman with rheumatoid arthritis treated with the tumor necrosis factor antagonist etanercept and suggest management strategies for early detection and management of this complication.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 653-656 |
| Number of pages | 4 |
| Journal | Mayo Clinic Proceedings |
| Volume | 76 |
| Issue number | 6 |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- DMARD = disease-modifying antirheumatic drug
- NSAID = nonsteroidal anti-inflammatory drug
- RA = rheumatoid arthritis
- WBC = white blood cell
ASJC Scopus subject areas
- Medicine(all)
Cite this
Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept. / Bachai, Mercedeh; Osmon, Douglas R.; Wolk, Donna; Wold, Lester E.; Haidukewych, George J.; Matteson, Eric L.
In: Mayo Clinic Proceedings, Vol. 76, No. 6, 2001, p. 653-656.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept
AU - Bachai, Mercedeh
AU - Osmon, Douglas R.
AU - Wolk, Donna
AU - Wold, Lester E.
AU - Haidukewych, George J.
AU - Matteson, Eric L.
PY - 2001
Y1 - 2001
N2 - Patients with long-standing, severe, erosive rheumatoid arthritis who have extra-articular manifestations and have undergone joint replacement surgery are at increased risk for serious infection and premature mortality. New therapies, including cytokine antagonists, hold great promise for improving the course of rheumatoid arthritis. However, they have powerful anti-inflammatory effects that may mask symptoms of serious infection. We report a case of fatal pneumococcal sepsis occurring in a 37-year-old woman with rheumatoid arthritis treated with the tumor necrosis factor antagonist etanercept and suggest management strategies for early detection and management of this complication.
AB - Patients with long-standing, severe, erosive rheumatoid arthritis who have extra-articular manifestations and have undergone joint replacement surgery are at increased risk for serious infection and premature mortality. New therapies, including cytokine antagonists, hold great promise for improving the course of rheumatoid arthritis. However, they have powerful anti-inflammatory effects that may mask symptoms of serious infection. We report a case of fatal pneumococcal sepsis occurring in a 37-year-old woman with rheumatoid arthritis treated with the tumor necrosis factor antagonist etanercept and suggest management strategies for early detection and management of this complication.
KW - DMARD = disease-modifying antirheumatic drug
KW - NSAID = nonsteroidal anti-inflammatory drug
KW - RA = rheumatoid arthritis
KW - WBC = white blood cell
UR - http://www.scopus.com/inward/record.url?scp=0034995201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034995201&partnerID=8YFLogxK
M3 - Article
VL - 76
SP - 653
EP - 656
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 6
ER -