FBXL21 association with schizophrenia in irish family and case-control samples

Xiangning Chen, Xu Wang, Cuie Sun, Qi Chen, F. Anthony O'Neill, Dermot Walsh, Ayman Fanous, Kenneth S. Kendler

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

FBXL21 gene encodes an F-box containing protein functioning in the SCF ubiquitin ligase complex. The role of the F-box protein is to recruit proteins designated for degradation to the ligase complex so they would be ubiquitinated. Using both family and case-control samples, we found consistent associations in and around FBXL21 gene. In the family sample (Irish study of high density schizophrenia families, ISHDSF, 1,350 subjects from 273 families), a minimal PDT P-value of 0.0011 was observed at rs31555. In the case-control sample (Irish case-control study of schizophrenia, ICCSS, 814 cases and 625 controls), significant associations were observed at two markers (rs1859427 P = 0.0197, and rs6861170 P = 0.0197). In haplotype analyses, haplotype 1-1 (C-T) of rs1859427-rs6861170 was overtransmitted in the ISHDSF (P = 0.0437) and was overrepresented in the ICCSS (P = 0.0177). For both samples, the associated alleles and haplotypes were identical. These data suggested that FBXL21 may be associated with schizophrenia in the Irish samples.

Original languageEnglish (US)
Pages (from-to)1231-1237
Number of pages7
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume147
Issue number7
DOIs
StatePublished - Oct 5 2008
Externally publishedYes

Keywords

  • Association
  • Pedigree disequilibrium test
  • Schizophrenia
  • Ubiquitination

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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