Feasibility of gadofosveset-enhanced steady-state magnetic resonance angiography of the peripheral vessels at 3 tesla with dixon fat saturation

Henrik J. Michaely, Ulrike I. Attenberger, Olaf Dietrich, Peter Schmitt, Kambiz Nael, Harald Kramer, Maximilian F. Reiser, Stefan O. Schoenberg, Michael Walz

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Introduction: To investigate the feasibility and image quality of gadofosveset-enhanced steady-state peripheral MR-angiography using Dixon fat saturation in comparison to spectral fat saturation. Materials and methods: After Institutional Review Board (IRB) approval, 10 healthy volunteers underwent peripheral MR-angiography at 3.0 T during the steady state 50 minutes after gadofosveset injection. A steady-state-adapted volume interpolated breathhold examination sequence with an isotropic spatial resolution of 1 mm was acquired with 2-point Dixon fat saturation (DixFS, acquisition time 52 seconds) and with conventional, spectral fat saturation (SFS, acquisition time 58 seconds). The quality of the images was rated on an ordinal 4-point scale (4, very good) by 2 radiologists in consensus. The signal-to-noise ratios (SNRs) of the vessels, the fat, and the muscles as well as the contrast-to-noise-ratio (CNR) between vessels, fat, and muscle were determined. Paired P tests were performed for statistical analysis with a significance level of P < 0.05. Results: Diagnostic image quality was achieved in all examinations. The image quality of the DixFS images was rated superior (median 4) over the SFS images (median 3; P ≤ 0.03). The SNR of muscles and vessels was 40% higher with DixFS (P < 0.008), whereas the SNR of fat was decreased by 40.3% from 40.7 with SFS to 22.4 with DixFS (P < 0.0001). The CNR (fat/muscle) of the DixFS images of 84.1/71.7 was significantly higher than the CNR of the SFS images of 47.7/47.4 (P < 0.001). Discussion: Two-point Dixon fat suppression for MR-angiography during the steady state after the administration of gadofosveset is feasible with superior image quality and more than 50% increase in CNR (fat/muscle) compared with spectral fat saturation without an additional time penalty.

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalInvestigative Radiology
Volume43
Issue number9
DOIs
StatePublished - Sep 2008
Externally publishedYes

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Magnetic Resonance Angiography
Fats
Noise
Signal-To-Noise Ratio
Muscles
Angiography
Research Ethics Committees
Healthy Volunteers

Keywords

  • 3 Tesla
  • Dixon fat saturation
  • Gadofosveset
  • Intravascular contrast agent
  • Magnetic resonance angiography
  • Peripheral arteries
  • Steady state

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Feasibility of gadofosveset-enhanced steady-state magnetic resonance angiography of the peripheral vessels at 3 tesla with dixon fat saturation. / Michaely, Henrik J.; Attenberger, Ulrike I.; Dietrich, Olaf; Schmitt, Peter; Nael, Kambiz; Kramer, Harald; Reiser, Maximilian F.; Schoenberg, Stefan O.; Walz, Michael.

In: Investigative Radiology, Vol. 43, No. 9, 09.2008, p. 635-641.

Research output: Contribution to journalArticle

Michaely, Henrik J. ; Attenberger, Ulrike I. ; Dietrich, Olaf ; Schmitt, Peter ; Nael, Kambiz ; Kramer, Harald ; Reiser, Maximilian F. ; Schoenberg, Stefan O. ; Walz, Michael. / Feasibility of gadofosveset-enhanced steady-state magnetic resonance angiography of the peripheral vessels at 3 tesla with dixon fat saturation. In: Investigative Radiology. 2008 ; Vol. 43, No. 9. pp. 635-641.
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abstract = "Introduction: To investigate the feasibility and image quality of gadofosveset-enhanced steady-state peripheral MR-angiography using Dixon fat saturation in comparison to spectral fat saturation. Materials and methods: After Institutional Review Board (IRB) approval, 10 healthy volunteers underwent peripheral MR-angiography at 3.0 T during the steady state 50 minutes after gadofosveset injection. A steady-state-adapted volume interpolated breathhold examination sequence with an isotropic spatial resolution of 1 mm was acquired with 2-point Dixon fat saturation (DixFS, acquisition time 52 seconds) and with conventional, spectral fat saturation (SFS, acquisition time 58 seconds). The quality of the images was rated on an ordinal 4-point scale (4, very good) by 2 radiologists in consensus. The signal-to-noise ratios (SNRs) of the vessels, the fat, and the muscles as well as the contrast-to-noise-ratio (CNR) between vessels, fat, and muscle were determined. Paired P tests were performed for statistical analysis with a significance level of P < 0.05. Results: Diagnostic image quality was achieved in all examinations. The image quality of the DixFS images was rated superior (median 4) over the SFS images (median 3; P ≤ 0.03). The SNR of muscles and vessels was 40{\%} higher with DixFS (P < 0.008), whereas the SNR of fat was decreased by 40.3{\%} from 40.7 with SFS to 22.4 with DixFS (P < 0.0001). The CNR (fat/muscle) of the DixFS images of 84.1/71.7 was significantly higher than the CNR of the SFS images of 47.7/47.4 (P < 0.001). Discussion: Two-point Dixon fat suppression for MR-angiography during the steady state after the administration of gadofosveset is feasible with superior image quality and more than 50{\%} increase in CNR (fat/muscle) compared with spectral fat saturation without an additional time penalty.",
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AU - Michaely, Henrik J.

AU - Attenberger, Ulrike I.

AU - Dietrich, Olaf

AU - Schmitt, Peter

AU - Nael, Kambiz

AU - Kramer, Harald

AU - Reiser, Maximilian F.

AU - Schoenberg, Stefan O.

AU - Walz, Michael

PY - 2008/9

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N2 - Introduction: To investigate the feasibility and image quality of gadofosveset-enhanced steady-state peripheral MR-angiography using Dixon fat saturation in comparison to spectral fat saturation. Materials and methods: After Institutional Review Board (IRB) approval, 10 healthy volunteers underwent peripheral MR-angiography at 3.0 T during the steady state 50 minutes after gadofosveset injection. A steady-state-adapted volume interpolated breathhold examination sequence with an isotropic spatial resolution of 1 mm was acquired with 2-point Dixon fat saturation (DixFS, acquisition time 52 seconds) and with conventional, spectral fat saturation (SFS, acquisition time 58 seconds). The quality of the images was rated on an ordinal 4-point scale (4, very good) by 2 radiologists in consensus. The signal-to-noise ratios (SNRs) of the vessels, the fat, and the muscles as well as the contrast-to-noise-ratio (CNR) between vessels, fat, and muscle were determined. Paired P tests were performed for statistical analysis with a significance level of P < 0.05. Results: Diagnostic image quality was achieved in all examinations. The image quality of the DixFS images was rated superior (median 4) over the SFS images (median 3; P ≤ 0.03). The SNR of muscles and vessels was 40% higher with DixFS (P < 0.008), whereas the SNR of fat was decreased by 40.3% from 40.7 with SFS to 22.4 with DixFS (P < 0.0001). The CNR (fat/muscle) of the DixFS images of 84.1/71.7 was significantly higher than the CNR of the SFS images of 47.7/47.4 (P < 0.001). Discussion: Two-point Dixon fat suppression for MR-angiography during the steady state after the administration of gadofosveset is feasible with superior image quality and more than 50% increase in CNR (fat/muscle) compared with spectral fat saturation without an additional time penalty.

AB - Introduction: To investigate the feasibility and image quality of gadofosveset-enhanced steady-state peripheral MR-angiography using Dixon fat saturation in comparison to spectral fat saturation. Materials and methods: After Institutional Review Board (IRB) approval, 10 healthy volunteers underwent peripheral MR-angiography at 3.0 T during the steady state 50 minutes after gadofosveset injection. A steady-state-adapted volume interpolated breathhold examination sequence with an isotropic spatial resolution of 1 mm was acquired with 2-point Dixon fat saturation (DixFS, acquisition time 52 seconds) and with conventional, spectral fat saturation (SFS, acquisition time 58 seconds). The quality of the images was rated on an ordinal 4-point scale (4, very good) by 2 radiologists in consensus. The signal-to-noise ratios (SNRs) of the vessels, the fat, and the muscles as well as the contrast-to-noise-ratio (CNR) between vessels, fat, and muscle were determined. Paired P tests were performed for statistical analysis with a significance level of P < 0.05. Results: Diagnostic image quality was achieved in all examinations. The image quality of the DixFS images was rated superior (median 4) over the SFS images (median 3; P ≤ 0.03). The SNR of muscles and vessels was 40% higher with DixFS (P < 0.008), whereas the SNR of fat was decreased by 40.3% from 40.7 with SFS to 22.4 with DixFS (P < 0.0001). The CNR (fat/muscle) of the DixFS images of 84.1/71.7 was significantly higher than the CNR of the SFS images of 47.7/47.4 (P < 0.001). Discussion: Two-point Dixon fat suppression for MR-angiography during the steady state after the administration of gadofosveset is feasible with superior image quality and more than 50% increase in CNR (fat/muscle) compared with spectral fat saturation without an additional time penalty.

KW - 3 Tesla

KW - Dixon fat saturation

KW - Gadofosveset

KW - Intravascular contrast agent

KW - Magnetic resonance angiography

KW - Peripheral arteries

KW - Steady state

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