Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer

Nam P. Nguyen, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Lexie Smith-Raymond, Michelle Stevie, Benjamin Slane, Alexander Chi, Anand Desai, Shane P. Krafft, Siyoung Jang, Russell J Hamilton, Ulf Karlsson, Dave Abraham

Research output: Contribution to journalArticle

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Abstract

Background: To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.Methods: A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed.Results: Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40 Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20 Gy on parotid dose (23 patients) and the conventional constraint (CC) of 26 Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1 Gy and 24.7 Gy for the SC and CC plans (p < 0.0001). The volume of contralateral parotid receiving 40 Gy or more was respectively 5.3% and 18.2% (p < 0.0001). Conclusion: Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.

Original languageEnglish (US)
Article number175
JournalBMC Cancer
Volume12
DOIs
StatePublished - May 11 2012

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Image-Guided Radiotherapy
Intensity-Modulated Radiotherapy
Head and Neck Neoplasms
Radiotherapy
Parotid Gland
Neck
Neoplasm Metastasis

Keywords

  • Head and neck cancer
  • Parotid sparing
  • Tomotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

Nguyen, N. P., Vos, P., Vinh-Hung, V., Ceizyk, M., Smith-Raymond, L., Stevie, M., ... Abraham, D. (2012). Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer. BMC Cancer, 12, [175]. https://doi.org/10.1186/1471-2407-12-175

Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer. / Nguyen, Nam P.; Vos, Paul; Vinh-Hung, Vincent; Ceizyk, Misty; Smith-Raymond, Lexie; Stevie, Michelle; Slane, Benjamin; Chi, Alexander; Desai, Anand; Krafft, Shane P.; Jang, Siyoung; Hamilton, Russell J; Karlsson, Ulf; Abraham, Dave.

In: BMC Cancer, Vol. 12, 175, 11.05.2012.

Research output: Contribution to journalArticle

Nguyen, NP, Vos, P, Vinh-Hung, V, Ceizyk, M, Smith-Raymond, L, Stevie, M, Slane, B, Chi, A, Desai, A, Krafft, SP, Jang, S, Hamilton, RJ, Karlsson, U & Abraham, D 2012, 'Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer', BMC Cancer, vol. 12, 175. https://doi.org/10.1186/1471-2407-12-175
Nguyen, Nam P. ; Vos, Paul ; Vinh-Hung, Vincent ; Ceizyk, Misty ; Smith-Raymond, Lexie ; Stevie, Michelle ; Slane, Benjamin ; Chi, Alexander ; Desai, Anand ; Krafft, Shane P. ; Jang, Siyoung ; Hamilton, Russell J ; Karlsson, Ulf ; Abraham, Dave. / Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer. In: BMC Cancer. 2012 ; Vol. 12.
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