Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy

Nam P. Nguyen, Shane P. Krafft, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Siyoung Jang, Anand Desai, Dave Abraham, Lars Ewell, Christopher J Watchman, Russell J Hamilton, Beng Hoey Jo, Ulf Karlsson, Lexie Smith-Raymond

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens. Patients and Methods: A retrospective review of 7 patients with Graves' ophthalmopathy who had radiotherapy because of disease progression on high steroid dose is reported: 3 patients were treated with tomotherapy and 4 patients with HBT. Results: Compared to HBT, tomotherapy may provide better target coverage and significant reduction of radiation dose to the lacrimal glands and a higher dose to the lens. The NSBT improved target coverage but resulted in significantly higher doses to the lens and lacrimal glands. Conclusion: Tomotherapy may provide better coverage of the target volume and may be more effective in reducing severe exophthalmos compared to the conventional radiotherapy technique.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalStrahlentherapie und Onkologie
Volume187
Issue number9
DOIs
StatePublished - Sep 2011

Fingerprint

Graves Ophthalmopathy
Lacrimal Apparatus
Radiotherapy
Lenses
Radiation
Exophthalmos
Disease Progression
Steroids

Keywords

  • Graves exophthalmos
  • Target coverage
  • Tomotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Nguyen, N. P., Krafft, S. P., Vos, P., Vinh-Hung, V., Ceizyk, M., Jang, S., ... Smith-Raymond, L. (2011). Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy. Strahlentherapie und Onkologie, 187(9), 568-574. https://doi.org/10.1007/s00066-011-2220-z

Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy. / Nguyen, Nam P.; Krafft, Shane P.; Vos, Paul; Vinh-Hung, Vincent; Ceizyk, Misty; Jang, Siyoung; Desai, Anand; Abraham, Dave; Ewell, Lars; Watchman, Christopher J; Hamilton, Russell J; Jo, Beng Hoey; Karlsson, Ulf; Smith-Raymond, Lexie.

In: Strahlentherapie und Onkologie, Vol. 187, No. 9, 09.2011, p. 568-574.

Research output: Contribution to journalArticle

Nguyen, NP, Krafft, SP, Vos, P, Vinh-Hung, V, Ceizyk, M, Jang, S, Desai, A, Abraham, D, Ewell, L, Watchman, CJ, Hamilton, RJ, Jo, BH, Karlsson, U & Smith-Raymond, L 2011, 'Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy', Strahlentherapie und Onkologie, vol. 187, no. 9, pp. 568-574. https://doi.org/10.1007/s00066-011-2220-z
Nguyen, Nam P. ; Krafft, Shane P. ; Vos, Paul ; Vinh-Hung, Vincent ; Ceizyk, Misty ; Jang, Siyoung ; Desai, Anand ; Abraham, Dave ; Ewell, Lars ; Watchman, Christopher J ; Hamilton, Russell J ; Jo, Beng Hoey ; Karlsson, Ulf ; Smith-Raymond, Lexie. / Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy. In: Strahlentherapie und Onkologie. 2011 ; Vol. 187, No. 9. pp. 568-574.
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