Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy

Nam P. Nguyen, Shane P. Krafft, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Siyoung Jang, Anand Desai, Dave Abraham, Lars Ewell, Christopher Watchman, Russ Hamilton, Beng Hoey Jo, Ulf Karlsson, Lexie Smith-Raymond

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens. Patients and Methods: A retrospective review of 7 patients with Graves' ophthalmopathy who had radiotherapy because of disease progression on high steroid dose is reported: 3 patients were treated with tomotherapy and 4 patients with HBT. Results: Compared to HBT, tomotherapy may provide better target coverage and significant reduction of radiation dose to the lacrimal glands and a higher dose to the lens. The NSBT improved target coverage but resulted in significantly higher doses to the lens and lacrimal glands. Conclusion: Tomotherapy may provide better coverage of the target volume and may be more effective in reducing severe exophthalmos compared to the conventional radiotherapy technique.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalStrahlentherapie und Onkologie
Volume187
Issue number9
DOIs
StatePublished - Sep 1 2011

Keywords

  • Graves exophthalmos
  • Target coverage
  • Tomotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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