Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy

Nam P. Nguyen, Shane P. Krafft, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Siyoung Jang, Anand Desai, Dave Abraham, Lars Ewell, Christopher Watchman, Russ Hamilton, Beng Hoey Jo, Ulf Karlsson, Lexie Smith-Raymond

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens. Patients and Methods: A retrospective review of 7 patients with Graves' ophthalmopathy who had radiotherapy because of disease progression on high steroid dose is reported: 3 patients were treated with tomotherapy and 4 patients with HBT. Results: Compared to HBT, tomotherapy may provide better target coverage and significant reduction of radiation dose to the lacrimal glands and a higher dose to the lens. The NSBT improved target coverage but resulted in significantly higher doses to the lens and lacrimal glands. Conclusion: Tomotherapy may provide better coverage of the target volume and may be more effective in reducing severe exophthalmos compared to the conventional radiotherapy technique.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalStrahlentherapie und Onkologie
Volume187
Issue number9
DOIs
StatePublished - Sep 1 2011

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Keywords

  • Graves exophthalmos
  • Target coverage
  • Tomotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Nguyen, N. P., Krafft, S. P., Vos, P., Vinh-Hung, V., Ceizyk, M., Jang, S., Desai, A., Abraham, D., Ewell, L., Watchman, C., Hamilton, R., Jo, B. H., Karlsson, U., & Smith-Raymond, L. (2011). Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy. Strahlentherapie und Onkologie, 187(9), 568-574. https://doi.org/10.1007/s00066-011-2220-z