Feedback signaling controls leading-edge formation during chemotaxis

Pascale G Charest, Richard A. Firtel

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Chemotactic cells translate shallow chemoattractant gradients into a highly polarized intracellular response that includes the localized production of PI(3,4,5)P3 on the side of the cell facing the highest chemoattractant concentration. Research over the past decade began to uncover the molecular mechanisms involved in this localized signal amplification controlling the leading edge of chemotaxing cells. These mechanisms have been shown to involve multiple positive feedback loops, in which the PI(3,4,5)P3 signal amplifies itself independently of the original stimulus, as well as inhibitory signals that restrict PI(3,4,5)P3 to the leading edge, thereby creating a steep intracellular PI(3,4,5)P3 gradient. Molecules involved in positive feedback signaling at the leading edge include the small G-proteins Rac and Ras, phosphatidylinositol-3 kinase and F-actin, as part of interlinked feedback loops that lead to a robust production of PI(3,4,5)P3.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume16
Issue number4
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Chemotaxis
Chemotactic Factors
Phosphatidylinositol 3-Kinase
Monomeric GTP-Binding Proteins
Actins
phosphoinositide-3,4,5-triphosphate
Research

ASJC Scopus subject areas

  • Genetics

Cite this

Feedback signaling controls leading-edge formation during chemotaxis. / Charest, Pascale G; Firtel, Richard A.

In: Current Opinion in Genetics and Development, Vol. 16, No. 4, 08.2006, p. 339-347.

Research output: Contribution to journalArticle

@article{f3c1334ead1e44189255ddfa0dc35c20,
title = "Feedback signaling controls leading-edge formation during chemotaxis",
abstract = "Chemotactic cells translate shallow chemoattractant gradients into a highly polarized intracellular response that includes the localized production of PI(3,4,5)P3 on the side of the cell facing the highest chemoattractant concentration. Research over the past decade began to uncover the molecular mechanisms involved in this localized signal amplification controlling the leading edge of chemotaxing cells. These mechanisms have been shown to involve multiple positive feedback loops, in which the PI(3,4,5)P3 signal amplifies itself independently of the original stimulus, as well as inhibitory signals that restrict PI(3,4,5)P3 to the leading edge, thereby creating a steep intracellular PI(3,4,5)P3 gradient. Molecules involved in positive feedback signaling at the leading edge include the small G-proteins Rac and Ras, phosphatidylinositol-3 kinase and F-actin, as part of interlinked feedback loops that lead to a robust production of PI(3,4,5)P3.",
author = "Charest, {Pascale G} and Firtel, {Richard A.}",
year = "2006",
month = "8",
doi = "10.1016/j.gde.2006.06.016",
language = "English (US)",
volume = "16",
pages = "339--347",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Feedback signaling controls leading-edge formation during chemotaxis

AU - Charest, Pascale G

AU - Firtel, Richard A.

PY - 2006/8

Y1 - 2006/8

N2 - Chemotactic cells translate shallow chemoattractant gradients into a highly polarized intracellular response that includes the localized production of PI(3,4,5)P3 on the side of the cell facing the highest chemoattractant concentration. Research over the past decade began to uncover the molecular mechanisms involved in this localized signal amplification controlling the leading edge of chemotaxing cells. These mechanisms have been shown to involve multiple positive feedback loops, in which the PI(3,4,5)P3 signal amplifies itself independently of the original stimulus, as well as inhibitory signals that restrict PI(3,4,5)P3 to the leading edge, thereby creating a steep intracellular PI(3,4,5)P3 gradient. Molecules involved in positive feedback signaling at the leading edge include the small G-proteins Rac and Ras, phosphatidylinositol-3 kinase and F-actin, as part of interlinked feedback loops that lead to a robust production of PI(3,4,5)P3.

AB - Chemotactic cells translate shallow chemoattractant gradients into a highly polarized intracellular response that includes the localized production of PI(3,4,5)P3 on the side of the cell facing the highest chemoattractant concentration. Research over the past decade began to uncover the molecular mechanisms involved in this localized signal amplification controlling the leading edge of chemotaxing cells. These mechanisms have been shown to involve multiple positive feedback loops, in which the PI(3,4,5)P3 signal amplifies itself independently of the original stimulus, as well as inhibitory signals that restrict PI(3,4,5)P3 to the leading edge, thereby creating a steep intracellular PI(3,4,5)P3 gradient. Molecules involved in positive feedback signaling at the leading edge include the small G-proteins Rac and Ras, phosphatidylinositol-3 kinase and F-actin, as part of interlinked feedback loops that lead to a robust production of PI(3,4,5)P3.

UR - http://www.scopus.com/inward/record.url?scp=33745607882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745607882&partnerID=8YFLogxK

U2 - 10.1016/j.gde.2006.06.016

DO - 10.1016/j.gde.2006.06.016

M3 - Article

C2 - 16806895

AN - SCOPUS:33745607882

VL - 16

SP - 339

EP - 347

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

IS - 4

ER -