Female infertility in mice lacking connexin 37

Alex Simon, Daniel A. Goodenough, En Li, David L. Paul

Research output: Contribution to journalArticle

515 Citations (Scopus)

Abstract

The signals regulating ovarian follicle development and the mechanisms by which they are communicated are largely undefined. At birth, the ovary contains primordial follicles consisting of meiotically arrested oocytes surrounded by a single layer of supporting (granulosa) cells. Periodically, subsets of primordial follicles undergo further development during which the oocyte increases in size and the granulosa cells proliferate, stratify and develop a fluid-filled antrum. After ovulation, oocytes resume meiosis and granulosa cells retained in the follicle differentiate into steroidogenic cells, forming the corpus luteum. It has been proposed that intercellular signalling through gap junction channels may influence aspects of follicular development. Gap junctions are aggregations of intercellular channels composed of connexins, a family of at least 13 related proteins that directly connect adjacent cells allowing the diffusional movement of ions, metabolites, and other potential signalling molecules. Here we show that connexin 37 is present in gap junctions between oocyte and granulosa cells and that connexin-37-deficient mice lack mature (Graafian) follicles, fail to ovulate and develop numerous inappropriate corpora lutea. In addition, oocyte development arrests before meiotic competence is achieved. Thus, cell-cell signalling through intercellular channels critically regulates the highly coordinated set of cellular interactions required for successful oogenesis and ovulation.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalNature
Volume385
Issue number6616
DOIs
StatePublished - Feb 6 1997
Externally publishedYes

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Female Infertility
Granulosa Cells
Oocytes
Gap Junctions
Ovarian Follicle
Corpus Luteum
Ovulation
Oogenesis
Connexins
Meiosis
Mental Competency
Ovary
mouse GJA4 protein
Parturition
Ions
Proteins

ASJC Scopus subject areas

  • General

Cite this

Simon, A., Goodenough, D. A., Li, E., & Paul, D. L. (1997). Female infertility in mice lacking connexin 37. Nature, 385(6616), 525-529. https://doi.org/10.1038/385525a0

Female infertility in mice lacking connexin 37. / Simon, Alex; Goodenough, Daniel A.; Li, En; Paul, David L.

In: Nature, Vol. 385, No. 6616, 06.02.1997, p. 525-529.

Research output: Contribution to journalArticle

Simon, A, Goodenough, DA, Li, E & Paul, DL 1997, 'Female infertility in mice lacking connexin 37', Nature, vol. 385, no. 6616, pp. 525-529. https://doi.org/10.1038/385525a0
Simon A, Goodenough DA, Li E, Paul DL. Female infertility in mice lacking connexin 37. Nature. 1997 Feb 6;385(6616):525-529. https://doi.org/10.1038/385525a0
Simon, Alex ; Goodenough, Daniel A. ; Li, En ; Paul, David L. / Female infertility in mice lacking connexin 37. In: Nature. 1997 ; Vol. 385, No. 6616. pp. 525-529.
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