Fentanyl-related compounds and derivatives

Current status and future prospects for pharmaceutical applications

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years. In this review, we outline the structural and corresponding synthetic strategies that have been used to understand the structure-biological activity relationship in fentanyl-related compounds and derivatives and their biological activity profiles. We discuss how changes in the scaffold structure can change biological and pharmacological activities. Finally, recent efforts to design and synthesize novel multivalent ligands that act as mu and delta opioid receptors and NK-1 receptors are discussed.

Original languageEnglish (US)
Pages (from-to)385-412
Number of pages28
JournalFuture Medicinal Chemistry
Volume6
Issue number4
DOIs
StatePublished - 2014

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Fentanyl
Neurokinin-1 Receptors
delta Opioid Receptor
mu Opioid Receptor
Structure-Activity Relationship
Pharmaceutical Preparations
Pharmacology
Ligands
Pain
Therapeutics

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

Cite this

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