Fentanyl-related compounds and derivatives: Current status and future prospects for pharmaceutical applications

Research output: Contribution to journalReview article

91 Scopus citations

Abstract

Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years. In this review, we outline the structural and corresponding synthetic strategies that have been used to understand the structure-biological activity relationship in fentanyl-related compounds and derivatives and their biological activity profiles. We discuss how changes in the scaffold structure can change biological and pharmacological activities. Finally, recent efforts to design and synthesize novel multivalent ligands that act as mu and delta opioid receptors and NK-1 receptors are discussed.

Original languageEnglish (US)
Pages (from-to)385-412
Number of pages28
JournalFuture Medicinal Chemistry
Volume6
Issue number4
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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