Fenvalerate treatment affects development of olfactory glomeruli in Manduca sexta

Rainer Wegerhoff, Wolfgang Rössler, Mark Higgins, Lynne A. Oland, Leslie P. Tolbert

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Low doses of fenvalerate, a widely used type-II pyrethroid insecticide, have been shown previously to produce abnormal olfactory centers in the brain and abnormal olfactory-mediated behavior in beetles (Wegerhoff et al. [1998] Neuroreport 9:3241-3245). Here, we use the experimental advantages of the moth Manduca sexta to explore the cellular changes that lead to these abnormalities. Our results indicate that treatment with fenvalerate may affect multiple aspects of the development of the primary olfactory centers, the antennal lobes, in Manduca, including ingrowth of olfactory receptor axons, axon fasciculation, and targeting within the antennal lobe, and intercellular signaling between the receptor axons and the glial cells that ordinarily surround and stabilize the developing olfactory glomeruli.

Original languageEnglish (US)
Pages (from-to)533-541
Number of pages9
JournalJournal of Comparative Neurology
Volume430
Issue number4
DOIs
StatePublished - Feb 19 2001

Keywords

  • Antennal lobe
  • Metamorphosis
  • Olfactory glomerulus
  • Olfactory system
  • Pyrethroids

ASJC Scopus subject areas

  • Neuroscience(all)

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