Fetal alcohol syndrome: inhibition of placental zinc transport as a potential mechanism for fetal growth retardation in the rat

Fayez K Ghishan, Rashmi Patwardhan, Harry L. Greene

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Growth retardation is one of the principal features of fetal alcohol syndrome. The cause of this growth retardation is unknown. Because of the clinical similarities between fetal alcohol syndrome and prenatal zinc deficiency, we studied in vivo the effect of short-term and long-term ethanol ingestion during pregnancy on placental transport of zinc in pair-fed rats. Our results indicate that both short- and long-term ethanol depressed zinc-65 uptake in the placenta and fetus by 40% and 30%, respectively, compared to pair-fed controls (p < 0.05). Total zinc concentration in fetuses of the long-term ethanol group was significantly decreased compared to pair-fed controls (p < 0.05). Although the mechanism of action of ethanol in producing the fetal alcohol syndrome maybe multiple, our findings suggest that a decrease in the availability of zinc to the fetus may represent one of the contributory factors in the growth retardation of fetal alcohol syndrome.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalThe Journal of Laboratory and Clinical Medicine
Volume100
Issue number1
StatePublished - 1982
Externally publishedYes

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Fetal Alcohol Spectrum Disorders
Fetal Growth Retardation
Zinc
Rats
Alcohols
Ethanol
Fetus
Growth
Placenta
Intercellular Signaling Peptides and Proteins
Eating
Availability
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Fetal alcohol syndrome : inhibition of placental zinc transport as a potential mechanism for fetal growth retardation in the rat. / Ghishan, Fayez K; Patwardhan, Rashmi; Greene, Harry L.

In: The Journal of Laboratory and Clinical Medicine, Vol. 100, No. 1, 1982, p. 45-52.

Research output: Contribution to journalArticle

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